Swine acute diarrhea syndrome coronavirus replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway.

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Tytuł:: Swine acute diarrhea syndrome coronavirus replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway.
Autorzy:: Zhang J; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Zhang L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Shi H; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Feng S; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Feng T; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Chen J; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Zhang X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Han Y; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Liu J; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Wang Y; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Ji Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Jing Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Liu D; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China.
Shi D; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China. Electronic address: .
Feng L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xiangfang District, Haping Road 678, Harbin, 150069, China. Electronic address: .
Źródło:: Virology [Virology] 2022 Jan 02; Vol. 565, pp. 96-105. Date of Electronic Publication: 2021 Oct 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: New York, Academic Press.
MeSH Terms:: MAP Kinase Signaling System*/drug effects
Virus Replication*/drug effects
Alphacoronavirus/*physiology
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Animals ; Apoptosis/drug effects ; Cell Line ; Cell Nucleus/metabolism ; Chlorocebus aethiops ; Gene Knockdown Techniques ; Host-Pathogen Interactions ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 3/genetics ; Protein Kinase Inhibitors/pharmacology ; Swine ; Vero Cells
References:: Biomed Res Int. 2020 Dec 31;2020:8827752. (PMID: 33426074)
Nature. 2018 Apr;556(7700):255-258. (PMID: 29618817)
Biosci Biotechnol Biochem. 2019 May;83(5):960-969. (PMID: 30730256)
Virology. 2015 Oct;484:181-193. (PMID: 26115165)
Virus Res. 2019 Nov;273:197752. (PMID: 31518629)
J Virol. 2002 Apr;76(7):3365-73. (PMID: 11884562)
Emerg Microbes Infect. 2020 Dec;9(1):439-456. (PMID: 32090691)
Nat Immunol. 2004 Nov;5(11):1109-15. (PMID: 15496950)
Biochimie. 2007 Jun-Jul;89(6-7):819-30. (PMID: 17343971)
Pharmacology. 2021;106(1-2):119-122. (PMID: 33011728)
J Virol. 2021 Jul 26;95(16):e0018721. (PMID: 34037422)
J Virol. 2007 Jan;81(2):446-56. (PMID: 17079328)
Virus Res. 2020 Jul 2;283:197961. (PMID: 32283129)
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):5889-92. (PMID: 8392180)
Mol Cell Biol. 2001 Jul;21(14):4725-36. (PMID: 11416148)
Emerg Infect Dis. 2017 Sep;23(9):. (PMID: 28654418)
J Virol. 2001 May;75(10):4871-7. (PMID: 11312358)
J Virol. 2001 Jul;75(14):6450-9. (PMID: 11413312)
Curr Probl Cancer. 2018 Mar - Apr;42(2):161-174. (PMID: 29706467)
J Biol Chem. 1998 Jul 17;273(29):18623-32. (PMID: 9660836)
J Biol Chem. 1995 Nov 17;270(46):27489-94. (PMID: 7499206)
J Virol. 1998 Aug;72(8):6406-13. (PMID: 9658081)
J Biol Chem. 2000 Dec 15;275(50):39435-43. (PMID: 10993883)
Nat Cell Biol. 2001 Mar;3(3):301-5. (PMID: 11231581)
Mol Cell Biol. 1999 Feb;19(2):1301-12. (PMID: 9891064)
Science. 2013 May 10;340(6133):701-6. (PMID: 23661752)
J Virol. 2007 Feb;81(3):1230-40. (PMID: 17108034)
EMBO J. 1998 May 1;17(9):2607-18. (PMID: 9564043)
Virus Res. 2010 Sep;152(1-2):50-8. (PMID: 20540975)
Oncogene. 2001 May 3;20(20):2606-10. (PMID: 11420671)
FEBS J. 2010 Jan;277(1):2-21. (PMID: 19843174)
J Virol. 1996 Nov;70(11):7744-51. (PMID: 8892895)
Science. 1995 Nov 24;270(5240):1326-31. (PMID: 7481820)
Nat Rev Microbiol. 2019 Mar;17(3):181-192. (PMID: 30531947)
J Virol. 2005 Aug;79(16):10308-29. (PMID: 16051824)
Virus Res. 2007 Nov;129(2):73-9. (PMID: 17764774)
Life Sci. 2005 Nov 19;78(1):82-90. (PMID: 16150462)
Med Sci Monit. 2011 Jun;17(6):RA148-54. (PMID: 21629204)
Science. 1993 Apr 16;260(5106):315-9. (PMID: 8385802)
Oncogene. 1998 Jul 30;17(4):527-32. (PMID: 9696047)
Annu Rev Microbiol. 2019 Sep 8;73:529-557. (PMID: 31226023)
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 Jan;35(1):50-54. (PMID: 31245952)
Trends Cell Biol. 1997 Sep;7(9):353-61. (PMID: 17708980)
J Neurosci. 2000 Jun 15;20(12):4563-72. (PMID: 10844026)
Antimicrob Agents Chemother. 2015 Feb;59(2):1088-99. (PMID: 25487801)
Methods Mol Biol. 2015;1282:1-23. (PMID: 25720466)
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4355-9. (PMID: 8633070)
Microbiol Mol Biol Rev. 2004 Jun;68(2):320-44. (PMID: 15187187)
Biochim Biophys Acta. 2007 Aug;1773(8):1213-26. (PMID: 17112607)
Biochem Biophys Res Commun. 1995 Aug 15;213(2):715-24. (PMID: 7646528)
J Virol. 2008 Aug;82(15):7475-82. (PMID: 18508903)
Contributed Indexing:: Keywords: Apoptosis; ERK pathway; Swine acute diarrhea syndrome coronavirus (SADS-CoV); Viral replication
Substance Nomenclature:: 0 (Protein Kinase Inhibitors)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SCR Organism:: Swine acute diarrhea syndrome coronavirus
Entry Date(s):: Date Created: 20211112 Date Completed: 20211208 Latest Revision: 20230103
Update Code:: 20240104
PubMed Central ID:: PMC8556614
DOI:: 10.1016/j.virol.2021.10.009
PMID:: 34768113
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Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered enteric coronavirus. We have previously shown that the caspase-dependent FASL-mediated and mitochondrion-mediated apoptotic pathways play a central role in SADS-CoV-induced apoptosis, which facilitates viral replication. However, the roles of intracellular signaling pathways in SADS-CoV-mediated cell apoptosis and the relative advantages that such pathways confer on the host or virus remain largely unknown. In this study, we show that SADS-CoV induces the activation of ERK during infection, irrespective of viral biosynthesis. The knockdown or chemical inhibition of ERK1/2 significantly suppressed viral protein expression and viral progeny production. The inhibition of ERK activation also circumvented SADS-CoV-induced apoptosis. Taken together, these data suggest that ERK activation is important for SADS-CoV replication, and contributes to the virus-mediated changes in host cells. Our findings demonstrate the takeover of a particular host signaling mechanism by SADS-CoV and identify a potential approach to inhibiting viral spread.
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