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Tytuł pozycji:

Toxicity Assessment of Long-Term Exposure to Non-Thermal Plasma Activated Water in Mice.

Tytuł:
Toxicity Assessment of Long-Term Exposure to Non-Thermal Plasma Activated Water in Mice.
Autorzy:
Nastasa V; Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, 'Ion Ionescu de la Brad' University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania.
Pasca AS; Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, 'Ion Ionescu de la Brad' University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania.
Malancus RN; Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, 'Ion Ionescu de la Brad' University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania.
Bostanaru AC; Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, 'Ion Ionescu de la Brad' University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania.
Ailincai LI; Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, 'Ion Ionescu de la Brad' University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania.
Ursu EL; 'Petru Poni' Institute of Macromolecular Chemistry, 41A Aleea Grigore Ghica-Voda, 700487 Iasi, Romania.
Vasiliu AL; 'Petru Poni' Institute of Macromolecular Chemistry, 41A Aleea Grigore Ghica-Voda, 700487 Iasi, Romania.
Minea B; Department of Surgery, Faculty of Dental Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy of Iasi, 16 Universitatii Street, 700115 Iași, Romania.
Hnatiuc E; Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, 'Ion Ionescu de la Brad' University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania.
Mares M; Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, 'Ion Ionescu de la Brad' University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania.
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 26; Vol. 22 (21). Date of Electronic Publication: 2021 Oct 26.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:
Anti-Infective Agents/*toxicity
Plasma Gases/*toxicity
Administration, Oral ; Animals ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents, Local/administration & dosage ; Anti-Infective Agents, Local/toxicity ; Biomarkers/blood ; Biomarkers/metabolism ; Cytokines/metabolism ; Dental Care/methods ; Humans ; Ki-67 Antigen/metabolism ; Mice ; Microscopy, Atomic Force ; Microscopy, Electron, Scanning ; Plasma Gases/administration & dosage ; Proliferating Cell Nuclear Antigen/metabolism ; Time Factors ; Tooth/chemistry ; Tooth/drug effects ; Tooth/ultrastructure ; Water/administration & dosage
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Contributed Indexing:
Keywords: GlidArc reactor; cytokine profile; immunohistochemistry; non-thermal plasma activated water (PAW); toxicity in mice
Substance Nomenclature:
0 (Anti-Infective Agents)
0 (Anti-Infective Agents, Local)
0 (Biomarkers)
0 (Cytokines)
0 (Ki-67 Antigen)
0 (Mki67 protein, mouse)
0 (Plasma Gases)
0 (Proliferating Cell Nuclear Antigen)
059QF0KO0R (Water)
Entry Date(s):
Date Created: 20211113 Date Completed: 20211214 Latest Revision: 20211214
Update Code:
20240104
PubMed Central ID:
PMC8583710
DOI:
10.3390/ijms222111534
PMID:
34768973
Czasopismo naukowe
Non-thermal plasma activated water (PAW) has recently emerged as a powerful antimicrobial agent. Despite numerous potential bio-medical applications, studies concerning toxicity in live animals, especially after long-term exposure, are scarce. Our study aimed to assess the effects of long-term watering with PAW on the health of CD1 mice. PAW was prepared from distilled water with a GlidArc reactor according to a previously published protocol. The pH was 2.78. The mice received PAW (experimental group) or tap water (control group) daily for 90 days as the sole water source. After 90 days, the following investigations were performed on the euthanatized animals: gross necropsy, teeth mineral composition, histopathology, immunohistochemistry, hematology, blood biochemistry, methemoglobin level and cytokine profile. Mice tolerated PAW very well and no adverse effects were observed during the entire period of the experiment. Histopathological examination of the organs and tissues did not reveal any structural changes. Moreover, the expression of proliferation markers PCNA and Ki67 has not been identified in the epithelium of the upper digestive tract, indicating the absence of any pre- or neoplastic transformations. The results of our study demonstrated that long-term exposure to PAW caused no toxic effects and could be used as oral antiseptic solution in dental medicine.
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