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Tytuł:
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Genomic insights into Salmonella Choleraesuis var. Kunzendorf outbreak reveal possible interspecies transmission.
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Autorzy:
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Papić B; University of Ljubljana, Veterinary Faculty, Institute of Microbiology and Parasitology, Gerbičeva 60, SI-1000 Ljubljana, Slovenia. Electronic address: .
Kušar D; University of Ljubljana, Veterinary Faculty, Institute of Microbiology and Parasitology, Gerbičeva 60, SI-1000 Ljubljana, Slovenia.
Mićunović J; University of Ljubljana, Veterinary Faculty, Institute of Microbiology and Parasitology, Gerbičeva 60, SI-1000 Ljubljana, Slovenia.
Vidrih Š; University of Ljubljana, Veterinary Faculty, National Veterinary Institute, Gerbičeva 60, SI-1000 Ljubljana, Slovenia.
Pirš M; University of Ljubljana, Faculty of Medicine, Institute of Microbiology and Immunology, Zaloška 4, SI-1000 Ljubljana, Slovenia.
Ocepek M; University of Ljubljana, Veterinary Faculty, Institute of Microbiology and Parasitology, Gerbičeva 60, SI-1000 Ljubljana, Slovenia.
Avberšek J; University of Ljubljana, Veterinary Faculty, Institute of Microbiology and Parasitology, Gerbičeva 60, SI-1000 Ljubljana, Slovenia.
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Źródło:
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Veterinary microbiology [Vet Microbiol] 2021 Dec; Vol. 263, pp. 109282. Date of Electronic Publication: 2021 Nov 11.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam, Elsevier Scientific Pub. Co.
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MeSH Terms:
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Bacterial Zoonoses*/epidemiology
Bacterial Zoonoses*/microbiology
Bacterial Zoonoses*/transmission
Disease Outbreaks*
Genome, Bacterial*/genetics
Salmonella Infections, Animal*/epidemiology
Salmonella enterica*/genetics
Animals ; Genomics ; Humans ; Sus scrofa ; Swine
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Contributed Indexing:
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Keywords: Domestic pig; Outbreak investigation; Salmonella Choleraesuis; Whole-genome sequencing; Wild boar
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Entry Date(s):
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Date Created: 20211117 Date Completed: 20211216 Latest Revision: 20211216
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Update Code:
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20240105
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DOI:
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10.1016/j.vetmic.2021.109282
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PMID:
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34785475
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Salmonella enterica serovar Choleraesuis is a host-adapted serovar that causes serious infections in domestic pigs and wild boars. Here, we investigated an outbreak of salmonellosis in domestic pigs in Slovenia, 2018-2019. To assess the outbreak, 18 isolates from domestic pigs, wild boars, wild boar meat and a human patient underwent whole-genome sequencing (WGS). All isolates were of sequence type (ST) 145 and harbored no antimicrobial resistance genes or AMR-associated mutations. A single transmission cluster (≤ 6 alleles) of spatially (< 100 km) and temporally linked isolates was observed, comprising isolates of pig (n = 9), wild boar (n = 2) and human (n = 1) origin, and suggesting possible interspecies transmission. In all outbreak-related animal cases, septicemic salmonellosis was observed, accompanied in some cases by enteric symptoms. All pig isolates were linked to a single intensive breeding farm that distributed growers to small family farms. The same transport vehicles were used to distribute growers to family farms and also to transport livestock between neighboring countries. Both isolates that originated from the imported wild boar meat were genetically distant (≥ 122 alleles) from the outbreak cluster. The present results indicate the importance of screening domestic pigs and proper disinfection of transport vehicles to control the spread of S. Choleraesuis.
(Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.)
