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Tytuł:
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Microfluidic nanomaterials: From synthesis to biomedical applications.
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Autorzy:
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Illath K; Department of Engineering Design, Indian Institute of Technology Madras, India.
Kar S; Department of Electrical Engineering, University of Cambridge, UK.
Gupta P; Department of Engineering Design, Indian Institute of Technology Madras, India.
Shinde A; Department of Engineering Design, Indian Institute of Technology Madras, India.
Wankhar S; Department of Bioengineering, Christian Medical College Vellore, Vellore, India.
Tseng FG; Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan.
Lim KT; Department of Biosystems Engineering, Kangwon National University, South Korea.
Nagai M; Department of Mechanical Engineering, Toyohashi University of Technology, Aichi, Japan.
Santra TS; Department of Engineering Design, Indian Institute of Technology Madras, India. Electronic address: .
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Źródło:
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Biomaterials [Biomaterials] 2022 Jan; Vol. 280, pp. 121247. Date of Electronic Publication: 2021 Nov 11.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Review
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Język:
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English
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Imprint Name(s):
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Publication: <1995-> : Amsterdam : Elsevier Science
Original Publication: [Guilford, England] : IPC Science and Technology Press, 1980-
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MeSH Terms:
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Nanostructures*/chemistry
Quantum Dots*
Biopolymers ; Lab-On-A-Chip Devices ; Microfluidics/methods
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Contributed Indexing:
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Keywords: Biomedical applications; Clinical evaluations; Microfluidics; Nanomaterials; Screening
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Substance Nomenclature:
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0 (Biopolymers)
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Entry Date(s):
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Date Created: 20211121 Date Completed: 20220314 Latest Revision: 20220314
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Update Code:
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20240105
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DOI:
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10.1016/j.biomaterials.2021.121247
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PMID:
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34801251
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Microfluidic platforms gain popularity in biomedical research due to their attractive inherent features, especially in nanomaterials synthesis. This review critically evaluates the current state of the controlled synthesis of nanomaterials using microfluidic devices. We describe nanomaterials' screening in microfluidics, which is very relevant for automating the synthesis process for biomedical applications. We discuss the latest microfluidics trends to achieve noble metal, silica, biopolymer, quantum dots, iron oxide, carbon-based, rare-earth-based, and other nanomaterials with a specific size, composition, surface modification, and morphology required for particular biomedical application. Screening nanomaterials has become an essential tool to synthesize desired nanomaterials using more automated processes with high speed and repeatability, which can't be neglected in today's microfluidic technology. Moreover, we emphasize biomedical applications of nanomaterials, including imaging, targeting, therapy, and sensing. Before clinical use, nanomaterials have to be evaluated under physiological conditions, which is possible in the microfluidic system as it stimulates chemical gradients, fluid flows, and the ability to control microenvironment and partitioning multi-organs. In this review, we emphasize the clinical evaluation of nanomaterials using microfluidics which was not covered by any other reviews. In the future, the growth of new materials or modification in existing materials using microfluidics platforms and applications in a diversity of biomedical fields by utilizing all the features of microfluidic technology is expected.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
