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Tytuł:
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Salvage Cord Blood Transplantation Using a Short-term Reduced-intensity Conditioning Regimen for Graft Failure.
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Autorzy:
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Suma S; Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan.
Yokoyama Y; Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan.; Department of Hematology, University of Tsukuba Hospital, Japan.
Momose H; Department of Hematology, University of Tsukuba Hospital, Japan.
Makishima K; Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan.
Kiyoki Y; Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan.
Sakamoto T; Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan.; Department of Hematology, University of Tsukuba Hospital, Japan.
Kusakabe M; Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan.; Department of Hematology, University of Tsukuba Hospital, Japan.
Kato T; Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan.; Department of Hematology, University of Tsukuba Hospital, Japan.
Kurita N; Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan.; Department of Hematology, University of Tsukuba Hospital, Japan.
Nishikii H; Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan.; Department of Hematology, University of Tsukuba Hospital, Japan.
Sakata-Yanagimoto M; Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan.; Department of Hematology, University of Tsukuba Hospital, Japan.
Obara N; Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan.; Department of Hematology, University of Tsukuba Hospital, Japan.
Hasegawa Y; Department of Hematology, Ibaraki Prefecture Central Hospital, Japan.
Chiba S; Department of Hematology, Faculty of Medicine, University of Tsukuba, Japan.; Department of Hematology, University of Tsukuba Hospital, Japan.
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Źródło:
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Internal medicine (Tokyo, Japan) [Intern Med] 2022 Jun 01; Vol. 61 (11), pp. 1673-1679. Date of Electronic Publication: 2021 Nov 20.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Tokyo, Japan : Japanese Society of Internal Medicine, [1992-
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MeSH Terms:
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Cord Blood Stem Cell Transplantation*
Graft vs Host Disease*/etiology
Hematopoietic Stem Cell Transplantation*/adverse effects
Humans ; Retrospective Studies ; Salvage Therapy/methods ; Transplantation Conditioning/methods ; Vidarabine/therapeutic use
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References:
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Biol Blood Marrow Transplant. 2010 Aug;16(8):1099-106. (PMID: 20172038)
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Contributed Indexing:
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Keywords: cord blood transplantation; graft failure; short-term reduced-intensity conditioning regimen
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Substance Nomenclature:
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FA2DM6879K (Vidarabine)
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Entry Date(s):
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Date Created: 20211122 Date Completed: 20220603 Latest Revision: 20220720
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Update Code:
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20240105
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PubMed Central ID:
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PMC9259308
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DOI:
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10.2169/internalmedicine.7836-21
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PMID:
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34803091
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Objective Graft failure (GF) is a life-threatening complication of hematopoietic stem cell transplantation (HSCT). A standardized conditioning regimen and an appropriate graft source of salvage HSCT for GF have not yet been established. Some case series have shown good hematopoietic recoveries after salvage HSCT using a short-term reduced-intensity preparative regimen consisting of fludarabine (30-90 mg/m 2 ), cyclophosphamide (2 g/m 2 ), and total-body irradiation (2 Gy). However, the dose of fludarabine has varied in these reports based on the clinical condition of the patients, resulting in very limited experiences with each dose of fludarabine. Methods We retrospectively analyzed 10 patients who developed GF after allogeneic HSCT and underwent salvage cord blood transplantation (CBT) using the above-mentioned conditioning regimen with a fixed dose (90 mg/m 2 ) of fludarabine. Results Eight patients (80.0%) achieved neutrophil engraftment within 30 days from salvage HSCT with a median of 21 (range, 17-23) days. The 1-year overall survival (OS) rate after the salvage HSCT was 50.0%, and the median OS was 281 (range, 23-1,638) days. Cumulative incidences of non-relapse mortality and relapse at 1 year were 50.0% and 10.0%, respectively. Conclusion CBT using this short-term reduced-intensity conditioning regimen may be a promising salvage therapy for GF.
