-
Tytuł:
-
The role of family history of Cancer in Oral Cavity Cancer.
-
Autorzy:
-
Fantozzi PJ; Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA. .
Bavarian R; Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.; Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
Tamayo I; Department of Statistics, Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA.
Bind MA; Department of Statistics, Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA.
Woo SB; Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.; Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
Villa A; Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.
-
Źródło:
-
Head & face medicine [Head Face Med] 2021 Nov 22; Vol. 17 (1), pp. 48. Date of Electronic Publication: 2021 Nov 22.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: [London] : BioMed Central, [2005]-
-
MeSH Terms:
-
Carcinoma, Squamous Cell*/epidemiology
Carcinoma, Squamous Cell*/genetics
Mouth Neoplasms*/epidemiology
Mouth Neoplasms*/genetics
Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Female ; Humans ; Male ; Retrospective Studies
-
References:
-
Int J Epidemiol. 2015 Feb;44(1):169-85. (PMID: 25613428)
Curr Probl Cancer. 2018 Sep;42(5):466-475. (PMID: 30049422)
Int J Cancer. 2008 Apr 15;122(8):1827-31. (PMID: 18076043)
Oral Dis. 2015 Sep;21(6):685-93. (PMID: 25809224)
Ann Oncol. 2013 Oct;24(10):2651-2656. (PMID: 23884440)
Oral Oncol. 2001 Jan;37(1):1-16. (PMID: 11120478)
Med Clin North Am. 2014 Nov;98(6):1299-321. (PMID: 25443678)
BMC Cancer. 2013 Nov 28;13:560. (PMID: 24286495)
Oral Oncol. 2013 Jan;49(1):1-8. (PMID: 22841678)
Arch Otolaryngol Head Neck Surg. 1995 Feb;121(2):157-60. (PMID: 7840922)
Oral Dis. 2008 Jul;14(5):419-27. (PMID: 18938267)
Nature. 2015 Jan 29;517(7536):576-82. (PMID: 25631445)
CA Cancer J Clin. 2021 Jan;71(1):7-33. (PMID: 33433946)
Cell Discov. 2019 Nov 26;5:57. (PMID: 31798960)
-
Contributed Indexing:
-
Keywords: Cancer; Family history; Immunosuppression; Oral cancer; Oral cavity; Risk factors
-
Entry Date(s):
-
Date Created: 20211123 Date Completed: 20211124 Latest Revision: 20211126
-
Update Code:
-
20240105
-
PubMed Central ID:
-
PMC8607727
-
DOI:
-
10.1186/s13005-021-00298-8
-
PMID:
-
34809651
-
Objectives: Oral and oropharyngeal squamous cell carcinoma (SCC) is the 10th most common cancer in the United States (8th in males, 13th in females), with an estimated 54,010 new cases expected in 2021, and is primarily associated with smoked tobacco, heavy alcohol consumption, areca nut use and persistent high-risk human papillomavirus (HPV). Family history of cancer (FHC) and family history of head and neck cancer (FHHNC) have been reported to play an important role in the development of OSCC. We aimed to investigate the role of FHC, FHHNC and personal history of cancer in first/second degree-relatives as co-risk factors for oral cancer.
Methods: This was a retrospective study of patients diagnosed with OSCC at the Division of Oral Medicine and Dentistry at Brigham and Women's Hospital and at the Division of Head and Neck Oncology at Dana Farber Cancer Institute. Conditional logistic regressions were performed to examine whether OSCC was associated with FHC and FHHNC of FDRs and SDRs, personal history of cancer and secondary risk factors.
Results: Overall, we did not find an association between FHC, FHHNC and OSCC risk, whereas patients with a cancer history in one of their siblings were 1.6-times more likely to present with an OSCC. When secondary risk factors were considered, patients with a history of oral leukoplakia and dysplasia had a 16-times higher risk of having an OSCC.
Conclusions: Our study confirmed that a previous history of oral leukoplakia or dysplasia was an independent risk factor for OSCC. A positive family history of cancer in one or more siblings may be an additional risk factor for OSCC.
(© 2021. The Author(s).)
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.
