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Tytuł:
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Role and mechanism of intraflagellar transport in mammalian spermiogenesis.
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Autorzy:
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Ge TT; Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Department of Histology and Embryology, School of Medicine, Yangzhou University, Yangzhou 225009, China.
Yuan L; Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Department of Histology and Embryology, School of Medicine, Yangzhou University, Yangzhou 225009, China.
Xu WH; Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Department of Histology and Embryology, School of Medicine, Yangzhou University, Yangzhou 225009, China.
Zheng Y; Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Department of Histology and Embryology, School of Medicine, Yangzhou University, Yangzhou 225009, China.
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Źródło:
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Yi chuan = Hereditas [Yi Chuan] 2021 Nov 20; Vol. 43 (11), pp. 1038-1049.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Beijing : Ke xue chu ban she,
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MeSH Terms:
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Flagella*/metabolism
Kinesins*/metabolism
Animals ; Biological Transport ; Cilia/metabolism ; Male ; Mice ; Spermatogenesis
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Contributed Indexing:
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Keywords: intraflagellar transport; male infertility; spermiogenesis
Local Abstract: [Publisher, Chinese] 纤毛/鞭毛是真核生物细胞表面伸出的进化保守的细胞器,独特的位置和特性使它们在细胞运动和信号传递等生命过程发挥重要作用。哺乳动物纤毛/鞭毛的组装和维持都依赖纤毛/鞭毛内运输(intraflagellar transport, IFT)。IFT是由IFT复合体A和复合体B在驱动蛋白或马达蛋白驱动下的双向运输系统。该过程可将货物蛋白在胞体的合成位点与纤毛/鞭毛尖端的装配位点之间进行运输。鞭毛是哺乳动物精子产生动力的特异性细胞器,其完整性对精子正常功能至关重要。近年来研究表明,IFT在哺乳动物精子鞭毛形成和雄性生殖能力方面必不可少。本文对参与IFT的蛋白在精子鞭毛形成中的作用和机制进行了综述,以探讨其在男性不育症中的发病机制,为不育症的诊断和治疗提供理论基础。.
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Substance Nomenclature:
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EC 3.6.4.4 (Kinesins)
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Entry Date(s):
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Date Created: 20211124 Date Completed: 20211125 Latest Revision: 20211204
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Update Code:
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20240105
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DOI:
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10.16288/j.yczz.21-206
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PMID:
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34815207
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Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the cell surface. The unique location and properties of cilia allow them to function in vital processes such as motility and signaling. Ciliary assembly and maintenance rely on intraflagellar transport (IFT). Bidirectional movement of IFT particles composed of IFT-A and IFT-B complexes is powered by kinesin-2 and dynein-2 motors. IFT delivers building blocks between their site of synthesis in the cell body and the ciliary assembly site at the tip of the cilium. The integrity of the flagellum, a specialized organelle of mammalian sperm to generate the motility, is critical for normal sperm function. Recent findings suggest that IFT is indispensable for sperm flagellum formation and male fertility in mice and human. In this review, we summarize the role and mechanisms of IFT proteins during enflagellation in spermiogenesis, thereby discussing the pathological mechanisms of male infertility and providing theoretical basis for the diagnosis and treatment of male infertility.
