-
Tytuł:
-
Immunohistochemistry for the diagnosis of renal epithelial neoplasms.
-
Autorzy:
-
Akgul M; Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, 12208, USA.
Williamson SR; Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA. Electronic address: .
-
Źródło:
-
Seminars in diagnostic pathology [Semin Diagn Pathol] 2022 Jan; Vol. 39 (1), pp. 1-16. Date of Electronic Publication: 2021 Nov 12.
-
Typ publikacji:
-
Journal Article; Review
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Philadelphia Pa : W.B. Saunders
Original Publication: Orlando, FL : Grune & Stratton, c1984-
-
MeSH Terms:
-
Kidney Neoplasms*/diagnosis
Kidney Neoplasms*/genetics
Neoplasms, Glandular and Epithelial*
Humans ; Immunohistochemistry ; Kidney
-
Entry Date(s):
-
Date Created: 20211126 Date Completed: 20211221 Latest Revision: 20211221
-
Update Code:
-
20240105
-
DOI:
-
10.1053/j.semdp.2021.11.001
-
PMID:
-
34823973
-
Despite the increasing number of newly identified renal neoplasms, the diagnosis of renal cell carcinoma (RCC) can usually be reached with careful histologic examination and a limited immunohistochemical (IHC) panel. Clear cell, papillary, chromophobe RCC and oncocytoma account for more than 90% of renal neoplasia in adults, and sophisticated ancillary tools are usually unnecessary. Renal tumors with entity-defining genetic alterations may ultimately require molecular confirmation via cytogenetics or sequencing technologies, such as RCC with TFE3, TFEB, or ALK gene rearrangements, or TFEB amplified RCC. In fumarate hydratase-deficient and succinate dehydrogenase-deficient RCC, highly specific IHC markers can strongly suggest the diagnosis. In the metastatic setting, PAX8 and carbonic anhydrase 9 are among the most helpful markers for confirming RCC and clear cell type, respectively; however, caution should be exercised in the absence of a current or historical renal mass. In diagnostically challenging cases, such as renal eosinophilic tumors with low-grade nuclear features, or infiltrative high-grade tumors, careful examination coupled with a judicious panel of IHC markers usually resolves the diagnosis. This review offers concise algorithms for diagnosis of kidney neoplasia with the latest recognized, provisional, and emerging entities to daily pathology practice.
(Copyright © 2021 Elsevier Inc. All rights reserved.)