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Tytuł:
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Design, Synthesis, and Antifungal Evaluation of Luotonin A Derivatives against Phytopathogenic Fungi.
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Autorzy:
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Wang RX; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
Du SS; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
Wang JR; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
Chu QR; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
Tang C; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
Zhang ZJ; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
Yang CJ; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
He YH; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
Li HX; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
Wu TL; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
Liu YQ; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.; State Key Laboratory of Grassland Agro-ecosystems, Lanzhou University, Lanzhou 730000, China.
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Źródło:
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Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Dec 08; Vol. 69 (48), pp. 14467-14477. Date of Electronic Publication: 2021 Nov 29.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Washington, American Chemical Society.
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MeSH Terms:
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Antifungal Agents*/pharmacology
Fungicides, Industrial*/pharmacology
Botrytis ; Fungi ; Pyrroles ; Quinones ; Structure-Activity Relationship
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Contributed Indexing:
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Keywords: Botrytis cinerea; antifungal activity; luotonin A; mechanism of action; phytopathogenic fungi
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Substance Nomenclature:
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0 (Antifungal Agents)
0 (Fungicides, Industrial)
0 (Pyrroles)
0 (Quinones)
0 (luotonin A)
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Entry Date(s):
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Date Created: 20211129 Date Completed: 20211209 Latest Revision: 20211214
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Update Code:
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20240104
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DOI:
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10.1021/acs.jafc.1c04242
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PMID:
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34843231
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Crop diseases caused by fungi threaten food security and exacerbate the food crisis. Inspired by the application of fungicide candidates from natural products in agrochemical discovery, a series of luotonin A derivatives were designed, synthesized, and evaluated for their antifungal activities against five plant fungi. Most of these compounds exhibited significant fungicidal activity against Botrytis cinerea in vitro with EC 50 values less than 1 μg/mL. Among them, compounds w7 , w8 , w12 , and w15 showed superior antifungal activity against B. cinerea with EC 50 values of 0.036, 0.050, 0.042, and 0.048 μg/mL, respectively, which were more potent than boscalid (EC 50 = 1.790 μg/mL). Preliminary mechanism studies revealed that compound w7 might pursue its antifungal activity by disrupting the fungal cell membrane and cell wall. Moreover, in vivo bioassay also indicated that compound w7 could be effective for the control of B. cinerea . The above results evidenced the potential of luotonin A derivatives as novel and promising candidate fungicides.