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Tytuł:
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Preparation and characterization of starch-cellulose interpenetrating network hydrogels based on sequential Diels-Alder click reaction and photopolymerization.
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Autorzy:
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Wei H; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, PR China. Electronic address: .
Li S; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, PR China.
Liu Z; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, PR China.
Chen H; The Third Hospital of Xinxiang Medical University, Xinxiang, PR China. Electronic address: .
Liu Y; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, PR China.
Li W; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, PR China.
Wang G; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, PR China.
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Źródło:
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International journal of biological macromolecules [Int J Biol Macromol] 2022 Jan 01; Vol. 194, pp. 962-973. Date of Electronic Publication: 2021 Nov 27.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Guildford, Eng., IPC Science and Technology Press.
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MeSH Terms:
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Click Chemistry*/methods
Cycloaddition Reaction*/methods
Photochemical Processes*
Cellulose/*chemistry
Hydrogels/*chemistry
Starch/*chemistry
Chemistry Techniques, Synthetic ; Cross-Linking Reagents/chemistry ; Fluorouracil/chemistry ; Hydrogels/chemical synthesis ; Molecular Structure ; Polymerization ; Spectrum Analysis
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Contributed Indexing:
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Keywords: Diels-Alder reaction; IPN hydrogels; Photopolymerization
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Substance Nomenclature:
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0 (Cross-Linking Reagents)
0 (Hydrogels)
9004-34-6 (Cellulose)
9005-25-8 (Starch)
U3P01618RT (Fluorouracil)
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Entry Date(s):
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Date Created: 20211201 Date Completed: 20220317 Latest Revision: 20220317
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Update Code:
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20240104
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DOI:
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10.1016/j.ijbiomac.2021.11.154
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PMID:
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34848242
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Herein, starch-cellulose interpenetrating network (IPN) hydrogels were fabricated by sequential Diels-Alder click reaction and photopolymerization in water. Moreover, β-cyclodextrin, a commonly used host molecule in supramolecular chemistry, was also introduced to improve the performance of the IPN hydrogel. Firstly, the starch-based dienes were synthesized by modifying starch with N-maleoyl-β-alanine, and the cellulose-based dienophiles were obtained by the reaction of cellulose and furfurylamide succinate; Secondly, the as-synthesized starch-based dienes, cellulose-based dienophiles, polymerizable β-cyclodextrin, crosslinker, and acrylamide were dissolved in water and obtained a transparent solution. The solution was maintained in a water bath of 50 °C for 3 h, forming the first network via catalyst-free click Diels-Alder reaction, subsequently, the second network was formed by photopolymerization. Their preparation conditions were optimized via one-factor experiments and their properties and structures were characterized. Finally, 5- fluorouracil (5-Fu) was used as a model drug to study the sustained release behavior of the drug-loaded hydrogels. Release profile was found to fit in Ritger-Peppas kinetic model and polymer relaxation and drug diffusion made a valuable contribution to drug release. Taking into account the virtues of easily controllable photopolymerization and catalyst-free Diels-Alder reaction, the strategy described here has a potential application in the preparation of IPN hydrogels.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
