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Tytuł:
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Establishment of an RI for the urine ammonia-to-creatinine ratio in dogs.
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Autorzy:
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Adrianowycz SE; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Castro RA; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Specht AJ; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Harris AN; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.; Division of Nephrology, Hypertension and Renal Transplantation, College of Medicine, University of Florida, Gainesville, Florida, USA.
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Źródło:
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Veterinary clinical pathology [Vet Clin Pathol] 2021 Dec; Vol. 50 (4), pp. 597-602. Date of Electronic Publication: 2021 Dec 01.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 1998- : Baton Rouge, LA : American Society for Veterinary Clinical Pathology
Original Publication: 1977-<1989> : Columbia, MO : Veterinary Practice Pub. Co.
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MeSH Terms:
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Ammonia*
Urinalysis*/veterinary
Animals ; Creatinine ; Dogs ; Kidney ; Reference Values
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References:
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Vet Clin Pathol. 2013 Dec;42(4):424-36. (PMID: 24320779)
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Grant Information:
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University of Florida Foundation
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Contributed Indexing:
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Keywords: acid-base; assay; canine; kidney; renal physiology; solute transport
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Substance Nomenclature:
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7664-41-7 (Ammonia)
AYI8EX34EU (Creatinine)
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Entry Date(s):
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Date Created: 20211202 Date Completed: 20220103 Latest Revision: 20220722
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Update Code:
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20240105
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PubMed Central ID:
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PMC9299733
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DOI:
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10.1111/vcp.13032
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PMID:
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34854107
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Background: Ammonia is produced and excreted by the kidney, contributing to systemic acid-base homeostasis through the production of bicarbonate. Disorders of acid-base balance can lead to many clinical problems and measuring ammonia excretion helps in determining if the kidneys are responding to acid-base challenges appropriately. Reference intervals are integral to clinical decision-making, and there is no current RI for the urine ammonia-to-creatinine ratio (UACR) in dogs.
Objective: This study aimed to generate an RI for the UACR in healthy adult dogs.
Methods: The study used adult, client-owned dogs that were presented to the University of Florida Primary Care and Dentistry service (n = 60). Physical examinations were performed and serum chemistry and urinalysis samples were obtained. Urine ammonia and creatinine concentrations were determined. Dogs were excluded if there were significant abnormalities in either their urinalysis or serum chemistry results. The RI for the UACR was calculated according to the recommendation of the American Society for Veterinary Clinical Pathology. Data were evaluated for correlation with serum bicarbonate, weight, age, and sex.
Results: The RIs for the UACR were 0.16-23.69 with 90% confidence intervals for the lower and upper limits of (0.13-1.17) and (20.50-23.75), respectively. No significant impact of age, sex, or weight was found. There was no discernable relationship between serum bicarbonate and UACR.
Conclusions: Establishing an RI for UACR in healthy adult dogs will allow for further studies to determine if alterations are observed during specific disease states.
(© 2021 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals LLC on behalf of American Society for Veterinary Clinical Pathology.)