Amide Proton Transfer MRI Could Be Used to Evaluate the Pathophysiological Status of White Matter Hyperintensities.

Tytuł:: Amide Proton Transfer MRI Could Be Used to Evaluate the Pathophysiological Status of White Matter Hyperintensities.
Autorzy:: Guo Z; Department of Medical Imaging, Guilin Medical University, Guilin, China.; Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Meng Z; Department of Medical Imaging, Guilin Medical University, Guilin, China.; Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Mu R; Department of Medical Imaging, Guilin Medical University, Guilin, China.; Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Qin X; Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Zhuang Z; Department of Medical Imaging, Guilin Medical University, Guilin, China.; Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Zheng W; Department of Medical Imaging, Guilin Medical University, Guilin, China.; Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Liu F; Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Zhu X; Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Źródło:: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2022 Jul; Vol. 56 (1), pp. 301-309. Date of Electronic Publication: 2021 Dec 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: <2005-> : Hoboken , N.J. : Wiley-Liss
Original Publication: Chicago, IL : Society for Magnetic Resonance Imaging, c1991-
MeSH Terms:: White Matter*/diagnostic imaging
White Matter*/pathology
Adult ; Aged ; Amides ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prospective Studies ; Protons
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Contributed Indexing:: Keywords: Fazekas scale; amide proton transfer; cerebral small vessel disease; normal-appearing white matter; white matter hyperintensities; white matter hyperintensity penumbra
Substance Nomenclature:: 0 (Amides)
0 (Protons)
Entry Date(s):: Date Created: 20211202 Date Completed: 20220614 Latest Revision: 20220712
Update Code:: 20240105
DOI:: 10.1002/jmri.28013
PMID:: 34854519
: Czasopismo naukowe

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Background: The pathophysiology of white matter hyperintensities (WMH) remains unclear, investigations of amide proton transfer (APT) signals in WMH disease may provide relevant pathophysiological information.
Purpose: To evaluate the APT signals differences and heterogeneity of WMH and adjacent normal-appearing white matter (NAWM) at different Fazekas grades and different locations.
Study Type: Prospective.
Population: In all, 180 WMH patients (age, 40-76; male/female, 77/103) and 59 healthy controls (age, 42-70; male/female, 23/36).
Field Strength/sequence: A 3 T; 3D fluid-attenuated inversion recovery (FLAIR), 3D APT-weighted (APTw).
Assessment: The mean APTw values (APTw mean ) and the APTw signals heterogeneity (APTw max-min ) among different grades WMH and NAWM and the APTw mean of the same grade deep WMH (DWMH) and paraventricular WMH (PWMH) were calculated and compared. Regions of interests were delineated on WMH lesions, NAWM and healthy white matter.
Statistical Tests: One-way analysis of variance (ANOVA); independent sample t test; Chi-square test. Significance level: P < 0.05.
Results: APTw mean among different grade WMH (from grade 0 to 3, 0.58 ± 0.14% vs. 0.29 ± 0.23% vs. 0.37 ± 0.24% vs. 0.61 ± 0.22%, respectively) were significantly different except between grade 1 and 2 (P = 0.27) and between grade 0 and 3 (P = 0.97). The differences in APTw mean between WMH and NAWM were significant (WMH vs. NAWM from grade 1 to 3, 0.29% ± 0.23% vs. 0.55% ± 0.27%; 0.37% ± 0.24% vs. 0.59% ± 0.22%; 0.61% ± 0.22% vs. 0.42% ± 0.24%, respectively). Lower APTw mean values were found only in grade 3 NAWM than other grades NAWM and controls. The APTw max-min values of grade 1-3 WMH (0.38% ± 0.27% vs. 0.51% ± 0.31% vs. 0.67% ± 0.34%, respectively) were significantly different. Higher APT mean values were found only in grade 2 PWMH (0.47% ± 0.22% vs. 0.32% ± 0.24%).
Data Conclusion: Significant differences of APT signals were found in WMH of different Fazekas grades and different locations.
Evidence Level: 2 TECHNICAL EFFICACY: Stage 3.
(© 2021 International Society for Magnetic Resonance in Medicine.)

Comment in: J Magn Reson Imaging. 2022 Jul;56(1):310-311. (PMID: 34939258)

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