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Tytuł:
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Τhe anthropometric and biochemical profile of pediatric non-alcoholic fatty liver disease: A systematic review and a meta-analysis.
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Autorzy:
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Vadarlis A; Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece; Department of Gastroenterology and Hepatology, General Hospital of Thessaloniki 'G. Papanikolaou', Greece.
Chantavaridou S; Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece; 4(th) Department of Pediatrics, General Hospital of Thessaloniki, 'Papageorgiou', Greece.
Kalopitas G; Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece; Division of Gastroenterology and Hepatology, 1(st) Department of Internal Medicine, AHEPA University Hospital, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.
Bakaloudi DR; Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.
Karanika E; Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.
Tsekitsidi E; Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.
Chourdakis M; Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece. Electronic address: .
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Źródło:
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Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2022 Jan; Vol. 41 (1), pp. 105-121. Date of Electronic Publication: 2021 Nov 23.
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Typ publikacji:
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Journal Article; Meta-Analysis; Systematic Review
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Język:
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English
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Imprint Name(s):
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Publication: <2004->: Kidlington, Oxford, U.K. : Elsevier
Original Publication: Edinburgh ; New York : Churchill Livingstone, c1982-
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MeSH Terms:
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Anthropometry*
Non-alcoholic Fatty Liver Disease/*diagnosis
Risk Assessment/*methods
Adolescent ; Biomarkers/blood ; Body Mass Index ; Case-Control Studies ; Child ; Female ; Humans ; Lipids/blood ; Male ; Risk Factors ; Waist Circumference
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Contributed Indexing:
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Keywords: Antropometry; Biochemical profile; Non-alcoholic fatty liver disease; Paediatric hepatology
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Substance Nomenclature:
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0 (Biomarkers)
0 (Lipids)
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Entry Date(s):
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Date Created: 20211206 Date Completed: 20220225 Latest Revision: 20220225
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Update Code:
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20240105
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DOI:
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10.1016/j.clnu.2021.11.016
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PMID:
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34872045
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Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in children and one of the leading indications for liver transplantation in adults. However, current screening methods are inadequate and are accompanied by several disadvantages. This meta-analysis aims to identify the anthropometrical and biochemical characteristics most commonly appearing in pediatric NAFLD that could contribute to the diagnosis of the disease in the every-day clinical setting.
Methods: A systematic search was conducted in major electronic databases (MEDLINE, Scopus and Embase) up to 15th of August 2021. Primary outcome was the comparison of the anthropometric characteristics, whereas secondary outcomes were the comparisons of biochemical profile, lipid profile, and metabolic parameters in children with NAFLD compared with age-matched healthy controls. Quality assessment was performed with Newcastle-Ottawa Scale (NOS) and results were expressed as mean differences with 95% confidence intervals.
Results: Sixty-four studies were included. Two different comparisons were designed regarding the body mass status. Statistically significant differences were demonstrated by comparing children with NAFLD vs lean/normal weighted controls in body weight (23.0 kg, 95% CI: 14.0-31.8, P < 0.00001), height (3.07 cm, 95% CI: 0.21-5.94, P = 0.04), ΒΜΙ (10 kg/m 2 , 95% CI: 8.36-11.7, P < 0.00001) and waist circumference 25.8 cm (95% CI: 20.6-30.9, P < 0.00001) and by comparing children with NAFLD vs overweight/obese controls in weight (6.81 kg, 95% CI: 3.81-9.81), height (3.18 cm, 95% CI: 1.24 to 5.13, P = 0.001), BMI (2.19 kg/m 2 , 95% CI: 1.76-2.62, P < 0.00001) and WC (7.35 cm, 95% CI: 6.20-8.49, P < 0.00001).
Conclusions: Anthropometrical and biochemical characteristics of children and adolescents with NAFLD are statistically significantly different compared to age-matched controls; these characteristics could be used to identify individuals at risk of developing NAFLD and related comorbidities.
Competing Interests: Conflict of interest No conflict for interest for any of the author.
(Copyright © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
