Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids.

Tytuł:: Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids.
Autorzy:: Larison B; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, 90095, USA. .; Center for Tropical Research, Institute of the Environment and Sustainability, University of California, Los Angeles, CA, 90095, USA. .
Pinho GM; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, 90095, USA.
Haghani A; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Zoller JA; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Li CZ; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Finno CJ; Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Farrell C; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
Kaelin CB; HudsonAlpha Institute for Biotechnology, Huntsville, AL, 35806, USA.; Department of Genetics, Stanford University, Stanford, CA, 94305, USA.
Barsh GS; HudsonAlpha Institute for Biotechnology, Huntsville, AL, 35806, USA.; Department of Genetics, Stanford University, Stanford, CA, 94305, USA.
Wooding B; Quagga Project, Elandsberg Farms, Hermon, 7308, South Africa.
Robeck TR; Zoological Operations, SeaWorld Parks and Entertainment, 7007 SeaWorld Drive, Orlando, FL, USA.
Maddox D; White Oak Conservation, 581705 White Oak Road, Yulee, FL, 32097, USA.
Pellegrini M; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
Horvath S; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. .; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA. .; Altos Labs, San Diego, CA, USA. .
Źródło:: Communications biology [Commun Biol] 2021 Dec 17; Vol. 4 (1), pp. 1412. Date of Electronic Publication: 2021 Dec 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-
MeSH Terms:: Age Distribution*
Epigenesis, Genetic*
Equidae/*genetics
Animals ; Endangered Species ; Epigenomics ; Equidae/physiology ; Horses/physiology ; Models, Genetic ; Population Dynamics ; Species Specificity
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Entry Date(s):: Date Created: 20211218 Date Completed: 20220110 Latest Revision: 20240404
Update Code:: 20240404
PubMed Central ID:: PMC8683477
DOI:: 10.1038/s42003-021-02935-z
PMID:: 34921240
: Czasopismo naukowe

Pełny tekst

Effective conservation and management of threatened wildlife populations require an accurate assessment of age structure to estimate demographic trends and population viability. Epigenetic aging models are promising developments because they estimate individual age with high accuracy, accurately predict age in related species, and do not require invasive sampling or intensive long-term studies. Using blood and biopsy samples from known age plains zebras (Equus quagga), we model epigenetic aging using two approaches: the epigenetic clock (EC) and the epigenetic pacemaker (EPM). The plains zebra EC has the potential for broad application within the genus Equus given that five of the seven extant wild species of the genus are threatened. We test the EC's ability to predict age in sister taxa, including two endangered species and the more distantly related domestic horse, demonstrating high accuracy in all cases. By comparing chronological and estimated age in plains zebras, we investigate age acceleration as a proxy of health status. An interaction between chronological age and inbreeding is associated with age acceleration estimated by the EPM, suggesting a cumulative effect of inbreeding on biological aging throughout life.
(© 2021. The Author(s).)

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