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Tytuł:
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Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm.
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Autorzy:
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Dubis J; Research and Development Centre, Regional Specialist Hospital, 51-124 Wroclaw, Poland.
Niepiekło-Miniewska W; Laboratory of Immunogenetics and Tissue Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.
Jędruchniewicz N; Research and Development Centre, Regional Specialist Hospital, 51-124 Wroclaw, Poland.
Sobczyński M; Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Witkiewicz W; Department of Vascular Surgery, Regional Specialist Hospital in Wroclaw, 51-124 Wrocław, Poland.
Zapotoczny N; Department of Vascular Surgery, Regional Specialist Hospital in Wroclaw, 51-124 Wrocław, Poland.
Kuśnierczyk P; Laboratory of Immunogenetics and Tissue Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.
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Źródło:
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Cells [Cells] 2021 Nov 30; Vol. 10 (12). Date of Electronic Publication: 2021 Nov 30.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel, Switzerland : MDPI
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MeSH Terms:
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Genetic Association Studies*
Genetic Predisposition to Disease*
Aortic Aneurysm, Abdominal/*genetics
HLA Antigens/*genetics
Receptors, KIR/*genetics
Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Case-Control Studies ; Coronary Artery Disease/genetics ; Female ; HLA Antigens/metabolism ; Haplotypes/genetics ; Humans ; Ligands ; Male ; Middle Aged ; Receptors, KIR/metabolism
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References:
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Contributed Indexing:
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Keywords: BMI; CAD; HLA; KIR; abdominal aortic aneurism; aneurysm diameter; genetics; immune cells
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Substance Nomenclature:
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0 (HLA Antigens)
0 (Ligands)
0 (Receptors, KIR)
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Entry Date(s):
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Date Created: 20211224 Date Completed: 20220119 Latest Revision: 20220119
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Update Code:
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20240105
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PubMed Central ID:
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PMC8699266
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DOI:
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10.3390/cells10123357
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PMID:
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34943866
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Abdominal aortic aneurysm (AAA) is an immune-mediated disease with a genetic component. The multifactorial pathophysiology is not clear and there is still no pharmacotherapy to slow the growth of aneurysms. The signal integration of cell-surface KIRs (killer cell immunoglobulin-like receptors) with HLA (ligands, human leukocyte class I antigen molecules) modulates the activity of natural killer immune cells. The genetic diversity of the KIR/HLA system is associated with the risk of immune disorders. This study was a multivariate analysis of the association between genetic variants of KIRs, HLA ligands, clinical data and AAA formation. Genotyping was performed by single polymerase chain reaction with sequence-specific primers using commercial assays. Patients with HLA-A-Bw4 have a larger aneurysm by an average of 4 mm ( p = 0.008). We observed a relationship between aneurysm diameter and BMI in patients with AAA and co-existing CAD; its shape was determined by the presence of HLA-A-Bw4. There was also a nearly 10% difference in KIR3DL1 allele frequency between the study and control groups. High expression of the cell surface receptor KIR3DL1 may protect, to some extent, against AAA. The presence of HLA-A-Bw4 may affect the rate of aneurysm growth and represents a potential regional pathogenetic risk of autoimmune injury to the aneurysmal aorta.
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