Greasing the inflammatory pathogenesis of viral pneumonias in diabetes.

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Abstrakt

Tytuł:: Greasing the inflammatory pathogenesis of viral pneumonias in diabetes.
Autorzy:: Damen MSMA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Alarcon PC; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Medical Scientist Training Program, Cincinnati Childrens Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Shah AS; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Divanovic S; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Medical Scientist Training Program, Cincinnati Childrens Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Źródło:: Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2022 May; Vol. 23 (5), pp. e13415. Date of Electronic Publication: 2022 Jan 05.
Typ publikacji:: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: <2002->: Oxford, UK : Blackwell Publishing
Original Publication: Oxford, UK : Blackwell Science, c2000-
MeSH Terms:: COVID-19*
Diabetes Mellitus, Type 2*/etiology
Influenza, Human*/complications
Influenza, Human*/pathology
Pneumonia, Viral*/complications
Humans ; Obesity/metabolism ; SARS-CoV-2
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Grant Information:: P30 DK078392 United States DK NIDDK NIH HHS; R01 DK099222 United States DK NIDDK NIH HHS; R01 HL157260 United States HL NHLBI NIH HHS; T32 GM063483 United States GM NIGMS NIH HHS
Contributed Indexing:: Keywords: SARS-CoV2; adipocytes; diabetes; immunometabolism; obesity
Entry Date(s):: Date Created: 20220106 Date Completed: 20220412 Latest Revision: 20221222
Update Code:: 20240104
PubMed Central ID:: PMC9771603
DOI:: 10.1111/obr.13415
PMID:: 34989117
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Type 2 diabetes (T2D) and obesity are independent risk factors for increased morbidity and mortality associated with influenza and SARS-CoV-2 infection. Skewed cellular metabolism shapes immune cell inflammatory responsiveness and function in obesity, T2D, and infection. However, altered immune cell responsiveness and levels of systemic proinflammatory mediators, partly independent of peripheral immune cell contribution, are linked with SARS-CoV-2-associated disease severity. Despite such knowledge, the role of tissue parenchymal cell-driven inflammatory responses, and specifically those dominantly modified in obesity (e.g., adipocytes), in influenza and SARS-CoV-2 infection pathogenesis remain poorly defined. Whether obesity-dependent skewing of adipocyte cellular metabolism uncovers inflammatory clades and promotes the existence of a 'pathogenic-inflammatory' adipocyte phenotype that amplifies SARS-CoV-2 infection diseases severity in individuals with obesity and individuals with obesity and T2D has not been examined. Here, using the knowledge gained from studies of immune cell responses in obesity, T2D, and infection, we highlight the key knowledge gaps underlying adipocyte cellular functions that may sculpt and grease pathogenic processes associated with influenza and SARS-CoV-2 disease severity in diabetes.
(© 2022 World Obesity Federation.)

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