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Tytuł:
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Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma.
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Autorzy:
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Shiraishi T; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Toyozumi T; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Sakata H; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Murakami K; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kano M; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Matsumoto Y; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yokoyama M; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Okada K; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kamata T; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Ryuzaki T; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kinoshita K; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hirasawa S; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Matsubara H; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
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Źródło:
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Oncology [Oncology] 2022; Vol. 100 (1), pp. 39-47. Date of Electronic Publication: 2021 Dec 06.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel, New York, Karger.
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MeSH Terms:
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B7-H1 Antigen/*metabolism
Biomarkers, Tumor/*metabolism
Esophageal Neoplasms/*metabolism
Esophageal Squamous Cell Carcinoma/*metabolism
Aged ; Animals ; B7-H1 Antigen/blood ; B7-H1 Antigen/genetics ; Biomarkers, Tumor/blood ; Cell Line, Tumor ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophageal Squamous Cell Carcinoma/mortality ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Squamous Cell Carcinoma/surgery ; Female ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Prognosis ; Solubility ; Survival Rate ; Xenograft Model Antitumor Assays ; Mice
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Contributed Indexing:
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Keywords: Enzyme-linked immunosorbent assay; Esophageal cancer; Programmed cell death ligand; Programmed cell death-1; Squamous cell carcinoma
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Substance Nomenclature:
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0 (B7-H1 Antigen)
0 (Biomarkers, Tumor)
0 (CD274 protein, human)
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Entry Date(s):
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Date Created: 20220106 Date Completed: 20220114 Latest Revision: 20240226
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Update Code:
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20240226
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DOI:
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10.1159/000518740
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PMID:
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34991094
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Introduction: We determined the soluble programmed cell death-1 ligand-1 (sPD-L1) concentration in patients with esophageal squamous cell carcinoma (ESCC), and confirmed the PD-L1 expression in resected specimens.
Methods: Blood samples were collected from 73 patients with histologically proven ESCC. The serum levels of sPD-L1 were measured using an enzyme-linked immunosorbent assay. The correlations between the sPD-L1 concentration and the expression of PD-L1 in tumor specimens and tumor depth, lymph node metastasis, disease stage, and various laboratory data were assessed.
Results: sPD-L1 levels in patients with high PD-L1 expression levels in tumor tissue were significantly higher than in patients with low PD-L1 expression levels (p = 0.042). The OS of the sPD-L1-high group was significantly worse than that of the low group (p = 0.028). Similarly, patients in whom a tissue specimen was PD-L1-positive group showed significantly poorer OS.
Conclusion: The sPD-L1 concentration was correlated with the PD-L1 expression in tissues. Patients with PD-L1-positive tissue specimens showed significantly higher sPD-L1 levels in comparison to PD-L1-negative cases. Furthermore, patients with high sPD-L1 expression levels had a significantly worse prognosis than those with low sPD-L1 expression levels, and patients with a PD-L1-positive tissue specimen had a significantly worse prognosis than patients in whom the tissue specimen showed a low PD-L1 expression level.
(© 2021 S. Karger AG, Basel.)
