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Tytuł:
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T-Cell Response against Varicella Zoster Virus in Patients with Multiple Sclerosis during Relapse and Remission.
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Autorzy:
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Pérez-Saldívar M; Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.
Ordoñez G; Department of Neuroimmunology, National Institute of Neurology and Neurosurgery 'Manuel Velasco Suarez' (INNN), Mexico City 14269, Mexico.
Pineda B; Department of Neuroimmunology, National Institute of Neurology and Neurosurgery 'Manuel Velasco Suarez' (INNN), Mexico City 14269, Mexico.
Sotelo J; Department of Neuroimmunology, National Institute of Neurology and Neurosurgery 'Manuel Velasco Suarez' (INNN), Mexico City 14269, Mexico.
Martínez-Palomo A; Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.
Flores-Rivera J; Clinical Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery 'Manuel Velasco Suarez' (INNN), Mexico City 14269, Mexico.
Espinosa-Cantellano M; Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.
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Źródło:
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International journal of molecular sciences [Int J Mol Sci] 2021 Dec 28; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 28.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel, Switzerland : MDPI, [2000-
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MeSH Terms:
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Herpesvirus 3, Human/*physiology
Multiple Sclerosis/*immunology
Multiple Sclerosis/*virology
T-Lymphocytes/*immunology
Adenoviridae/physiology ; Adult ; Antibodies, Viral/immunology ; Cytokines/metabolism ; Female ; Herpesvirus 3, Human/immunology ; Herpesvirus 4, Human/immunology ; Herpesvirus 4, Human/physiology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Male ; Multiple Sclerosis, Relapsing-Remitting/immunology ; Multiple Sclerosis, Relapsing-Remitting/virology ; Recurrence ; Remission Induction
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Grant Information:
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CB-2016-01-287347 Consejo Nacional de Ciencia y Tecnología; SALUD-2015-1-261698 Consejo Nacional de Ciencia y Tecnología; Scholarship number 481492 Consejo Nacional de Ciencia y Tecnología; SEP-Cinvestav_FIDSC2018-17 Mexican Ministry of Education; Support for Research Activities Miguel Alemán Foundation
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Contributed Indexing:
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Keywords: autoimmune disease; multiple sclerosis; virus
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Substance Nomenclature:
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0 (Antibodies, Viral)
0 (Cytokines)
0 (Immunoglobulin G)
0 (Immunoglobulin M)
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Entry Date(s):
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Date Created: 20220111 Date Completed: 20220202 Latest Revision: 20220202
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Update Code:
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20240104
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PubMed Central ID:
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PMC8745673
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DOI:
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10.3390/ijms23010298
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PMID:
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35008726
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An association between varicella zoster virus (VZV) and multiple sclerosis (MS) has been reported in Mexican populations. The aim of this study was to compare the response of T cells from MS patients, during relapse and remission, to in vitro stimulation with VZV, adenovirus (AV) and Epstein-Barr virus (EBV). Proliferation and cytokine secretion of T cells from 29 relapsing-remitting MS patients and 38 healthy controls (HC) were analyzed by flow cytometry after stimulating with VZV, AV or EBV. IgG and IgM levels against VZV and EBV were quantified using Enzyme-Linked Immunosorbent Assay. Relapsing MS patients showed a higher percentage of responding CD4+ and CD8+ T cells against VZV compared to AV. In HC and remitting MS patients, proliferation of CD4+ T cells was higher when stimulated with VZV as compared to EBV. Moreover, T cells isolated from remitting patients secreted predominantly Th1 cytokines when cell cultures were stimulated with VZV. Finally, high concentration of anti-VZV IgG was found in sera from patients and controls. The results support previous studies of an VZV-MS association in the particular population studied and provide additional information about the possible role of this virus in the pathogenesis of MS.
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