Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid.

Tytuł:: Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid.
Autorzy:: Li JW; Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Wang JY; Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Yu RQ; Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Huo L; Department of Orthodontics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Zheng LW; Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China. .
Źródło:: BMC research notes [BMC Res Notes] 2022 Jan 10; Vol. 15 (1), pp. 12. Date of Electronic Publication: 2022 Jan 10.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : Biomed Central, 2008.
MeSH Terms:: Bone Density Conservation Agents*
Diphosphonates*
Animals ; Femur ; Rats ; Tooth Extraction ; Zoledronic Acid
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Grant Information:: 201910159268 Seed Fund for Basic Research, the University of Hong Kong
Contributed Indexing:: Keywords: Angiogenic markers; Animal model; Gene expression; Medication-related osteonecrosis of the jaw; Zoledronic acid
Substance Nomenclature:: 0 (Bone Density Conservation Agents)
0 (Diphosphonates)
6XC1PAD3KF (Zoledronic Acid)
Entry Date(s):: Date Created: 20220111 Date Completed: 20220112 Latest Revision: 20220114
Update Code:: 20240104
PubMed Central ID:: PMC8751108
DOI:: 10.1186/s13104-021-05900-5
PMID:: 35012647
: Czasopismo naukowe

Pełny tekst

Objectives: This study aimed to investigate the gene expression of angiogenic marker in surgically treated jawbones and femur on a rat model administrated with zoledronic acid.
Results: No soft tissue fenestration or bone exposure was found in femur. Delayed soft tissue healing was found in both ZA group (3 in mandible, 4 in maxilla) and control group (1 in mandible, 2 in maxilla), while exposed bone was found only in the ZA group (1 in maxilla, 2 in mandible). RT-PCR analysis demonstrated no significant difference in gene expression of angiogenetic markers between ZA-treated and control groups in femur and mandible. In the maxilla, the expression of VEGFA and VEGFR-2 in medium-term ZA group was significantly down-regulated compared with that in the control. The ZA treatment does not change significantly the expression of the angiogenic factors in femur and mandible, but significantly downregulates the expression in maxilla in this rat model. The angiogenesis inhibition may contribute to the development of MRONJ but does not play a key role.
(© 2021. The Author(s).)

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