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Tytuł:
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Correlation between abnormal thyroid function test and thyroid autoimmunity: a systematic review and meta-analysis.
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Autorzy:
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Xiao N; Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
Li Y; Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
Chen W; Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
Liu Y; Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
Li D; Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
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Źródło:
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Annals of palliative medicine [Ann Palliat Med] 2021 Dec; Vol. 10 (12), pp. 12690-12698.
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Typ publikacji:
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Journal Article; Meta-Analysis; Systematic Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Hong Kong : AME Publishing Company
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MeSH Terms:
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Thyroid Function Tests*
Thyroid Gland*
Autoimmunity ; Humans
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Contributed Indexing:
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Keywords: Thyroid; meta-analysis; thyroid autoimmune disease; thyroid function test
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Entry Date(s):
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Date Created: 20220112 Date Completed: 20220113 Latest Revision: 20220113
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Update Code:
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20240104
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DOI:
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10.21037/apm-21-3534
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PMID:
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35016433
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Background: This study was to analyze the correlation between abnormal thyroid function detection and thyroid autoimmune disease, so as to provide theoretical guidance for clinical diagnosis of thyroid autoimmune disease.
Methods: The Chinese databases were searched with a combination of words "thyroid", "thyroid autoimmune disease", "thyroid function testing", "meta-analysis". The entire database was searched in English language databases with the search terms "thyroid", "thyroid autoimmune disease", "thyroid function test ", "meta-analysis". Review manager software was applied for meta-analysis.
Results: A total of 8 articles were finally included. 4 articles reported the T3 level, showing P=0.95, I2=0%, odds ratio (OR) =2.39, 95% confidence interval (CI): 0.79-7.25; 3 articles reported the T4 levels, showing P=0.81, I2=0%, OR =2.16, 95% CI: 0.43-10.71; and 4 articles reported the thyroid stimulating hormone (TSH) level, showing P=0.48, I2=0%, OR =3.20, 95% CI: 1.45-7.07.
Discussion: After a systematic review of the literature, a significant difference was found in T3 and TSH levels between patients with autoimmune thyroid disease and those with a healthy thyroid, but the difference in T4 level was not significant.
