GDNF neurotrophic factor signalling determines the fate of dermal fibroblasts in wound-induced hair neogenesis and skin regeneration.

Tytuł:: GDNF neurotrophic factor signalling determines the fate of dermal fibroblasts in wound-induced hair neogenesis and skin regeneration.
Autorzy:: Vishlaghi N; Biology Department, Cox Science Center, University of Miami, Coral Gables, Florida, USA.
Rieger S; Biology Department, Cox Science Center, University of Miami, Coral Gables, Florida, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida, USA.
McGaughey V; Biology Department, Cox Science Center, University of Miami, Coral Gables, Florida, USA.
Lisse TS; Biology Department, Cox Science Center, University of Miami, Coral Gables, Florida, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Źródło:: Experimental dermatology [Exp Dermatol] 2022 Apr; Vol. 31 (4), pp. 577-581. Date of Electronic Publication: 2022 Jan 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Original Publication: Copenhagen : Munksgaard, c1992-
MeSH Terms:: Glial Cell Line-Derived Neurotrophic Factor*
Skin*
Animals ; Fibroblasts ; Hair ; Regeneration ; Transforming Growth Factor beta ; Wound Healing/genetics
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Grant Information:: R01 CA215973 United States CA NCI NIH HHS
Contributed Indexing:: Keywords: GDNF; GFRA1; RET; fibroblasts; hair follicles; regeneration; skin; stem cells; wound healing; wound repair
Substance Nomenclature:: 0 (Glial Cell Line-Derived Neurotrophic Factor)
0 (Transforming Growth Factor beta)
Entry Date(s):: Date Created: 20220112 Date Completed: 20220408 Latest Revision: 20220731
Update Code:: 20240104
PubMed Central ID:: PMC9306530
DOI:: 10.1111/exd.14526
PMID:: 35020233
: Czasopismo naukowe

Pełny tekst

We propose that GDNF, a glial cell line-derived neurotrophic factor, can promote hair follicle neogenesis and skin regeneration after wounding by directing the fate of dermal fibroblasts. Our hypothesis is largely based on detailed GDNF and receptor analysis during skin regenerative stages, as well as the induction of GDNF receptors after wounding between the pro-regenerative spiny mouse (genus Acomys) and its less-regenerative descendant, the house mouse (Mus musculus). To characterize the GDNF-target cells, we will conduct a series of lineage-tracing experiments in conjunction with single-cell RNA and assay for transposase-accessible chromatin sequencing experiments. The heterogenetic dynamics of skin regeneration have yet to be fully defined, and this research will help to advance the fields of regenerative medicine and biology. Finally, we believe that stimulating the GDNF signalling pathway in fibroblasts from less-regenerative animals, such as humans, will promote skin regeneration, morphogenesis and scarless wound healing.
(© 2022 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.)

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