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Tytuł:
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Glycol chitosan/iron oxide/polypyrrole nanoclusters for precise chemodynamic/photothermal synergistic therapy.
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Autorzy:
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Quiñones ED; Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.
Lu TY; Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.
Liu KT; Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.
Fan YJ; School of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; International Ph.D. Program in Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Chuang EY; Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei 11031, Taiwan; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan; International Ph.D. Program in Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. Electronic address: .
Yu J; Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan. Electronic address: .
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Źródło:
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International journal of biological macromolecules [Int J Biol Macromol] 2022 Apr 01; Vol. 203, pp. 268-279. Date of Electronic Publication: 2022 Jan 18.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Guildford, Eng., IPC Science and Technology Press.
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MeSH Terms:
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Photothermal Therapy*
Polymers*
Cell Line, Tumor ; Chitosan ; Ferric Compounds ; Pyrroles/pharmacology
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Contributed Indexing:
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Keywords: Magnetic resonance imaging; Photothermal and chemodynamic treatment; pH-targeting
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Substance Nomenclature:
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0 (Ferric Compounds)
0 (Polymers)
0 (Pyrroles)
0 (glycol-chitosan)
1K09F3G675 (ferric oxide)
30604-81-0 (polypyrrole)
9012-76-4 (Chitosan)
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Entry Date(s):
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Date Created: 20220120 Date Completed: 20220331 Latest Revision: 20220401
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Update Code:
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20240105
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DOI:
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10.1016/j.ijbiomac.2022.01.085
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PMID:
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35051505
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Noninvasive photothermal therapy (PTT) represents a promising direction for more modern and precise medical applications. However, PTT efficacy is still not satisfactory due to the existence of heat shock proteins (HSPs) and poorly targeted delivery. Herein, the design of a nanosystem with improved delivery efficacy for anticancer treatment employing the synergetic effects of reactive oxygen species (ROS)-driven chemodynamic therapy (CDT) to inactivated HSPs with photothermal-hyperthermia was therefore achieved through the development of pH-targeting glycol chitosan/iron oxide enclosed core polypyrrole nanoclusters (GCPI NCs). The designed NCs effectively accumulated toward cancer cells due to their acidic microenvironment, initiating ROS generation via Fenton reaction at the outset and performing site-specific near infrared (NIR)-photothermal effect. A comprehensive analysis of both surface and bulk material properties of the CDT/PTT NCs as well as biointerface properties were ascertained via numerous surface specific analytical techniques by bringing together heightened accumulation of CDT/PTT NCs, which can significantly eradicate cancer cells thus minimizing the side effects of conventional chemotherapies. All of these attributes act in synergy over the cancer cells succeeding in fashioning NC's able to act as competent agents in the MRI-monitored enhanced CDT/PTT synergistic therapy. Findings in this study evoke attention in future oncological therapeutic strategies.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
