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Tytuł:
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Prognostic Impact of Inflammation-Based Scores for Extrahepatic Cholangiocarcinoma.
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Autorzy:
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Asakura R; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Yanagimoto H; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Ajiki T; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Tsugawa D; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Mizumoto T; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
So S; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Urade T; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Nanno Y; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Fukushima K; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Gon H; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Komatsu S; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Kuramitsu K; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Goto T; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Asari S; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Kido M; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Toyama H; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
Fukumoto T; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe City, Japan.
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Źródło:
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Digestive surgery [Dig Surg] 2022; Vol. 39 (2-3), pp. 65-74. Date of Electronic Publication: 2022 Jan 20.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel ; New York : S. Karger, [c1984-
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MeSH Terms:
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Bile Duct Neoplasms*/pathology
Bile Duct Neoplasms*/surgery
Cholangiocarcinoma*/pathology
Cholangiocarcinoma*/surgery
Bile Ducts, Intrahepatic/pathology ; Humans ; Inflammation ; Prognosis ; Retrospective Studies
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Contributed Indexing:
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Keywords: C-reactive protein to albumin ratio; Extrahepatic cholangiocarcinoma; Inflammation-based score; Surgical resection
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Entry Date(s):
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Date Created: 20220120 Date Completed: 20220615 Latest Revision: 20220615
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Update Code:
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20240105
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DOI:
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10.1159/000521969
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PMID:
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35051946
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Introduction: Although the relationship between systemic inflammatory responses and prognosis has been known in various cancers, it remains unclear which scores are most valuable for determining the prognosis of extrahepatic cholangiocarcinoma. We aimed to verify the usefulness of various inflammation-based scores as prognostic factors in patients with resected extrahepatic cholangiocarcinoma.
Methods: We analyzed consecutive patients undergoing surgical resection for extrahepatic cholangiocarcinoma at our institution between January 2000 and December 2019. The usefulness of the following inflammation-based scores as prognostic factor was investigated: glasgow prognostic score (GPS), modified GPS, neutrophil-to-lymphocyte ratio, platelet to lymphocyte ratio, lymphocyte-to-monocyte ratio, prognostic nutrition index, C-reactive protein to albumin ratio (CAR), controlling nutritional status (CONUT), and prognostic index.
Results: A total of 169 patients were enrolled in this study. Of the nine scores, CAR and CONUT indicated prognostic value. Furthermore, multivariate analysis for overall survival revealed that high CAR (>0.23) was an independent prognostic factor (hazard ratio: 1.816, 95% confidence interval: 1.135-2.906, p = 0.0129), along with lymph node metastasis and curability. There was no difference in tumor staging and short-term outcomes between the low CAR (≤0.23) and high CAR groups.
Conclusions: CAR was the most valuable prognostic score in patients with resected extrahepatic cholangiocarcinoma.
(© 2022 S. Karger AG, Basel.)
