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Tytuł:
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Ancillary studies on cell blocks from fine needle aspiration specimens of salivary gland lesions: A multi-institutional study.
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Autorzy:
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Tabibi S; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gabrielson M; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Saoud C; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Davis K; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Wangsiricharoen S; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Lu R; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Tondi Resta I; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Viswanathan K; Department of Pathology, Emory University Hospital Midtown, Atlanta, Georgia, USA.
Faquin WC; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Baloch Z; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Maleki Z; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Źródło:
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Diagnostic cytopathology [Diagn Cytopathol] 2022 May; Vol. 50 (5), pp. 235-252. Date of Electronic Publication: 2022 Jan 29.
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Typ publikacji:
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Journal Article; Multicenter Study
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Język:
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English
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Imprint Name(s):
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Publication: New York Ny : Wiley-Liss
Original Publication: [New York, NY : Igaku-Shoin Medical Publishers, c1985-
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MeSH Terms:
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Salivary Gland Neoplasms*/diagnosis
Salivary Gland Neoplasms*/pathology
Biopsy, Fine-Needle ; Histocytochemistry ; Humans ; Retrospective Studies ; Salivary Glands/pathology
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References:
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Contributed Indexing:
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Keywords: Milan System for Reporting Cytology; ancillary studies; cell block; fine-needle aspiration; histochemistry stains; immunohistochemistry; in situ hybridization; salivary gland
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Entry Date(s):
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Date Created: 20220129 Date Completed: 20220405 Latest Revision: 20220729
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Update Code:
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20240105
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PubMed Central ID:
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PMC9303557
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DOI:
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10.1002/dc.24939
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PMID:
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35092649
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Background: Ancillary studies are commonly performed on cell blocks prepared from fine-needle aspiration (FNA) specimens. There are limited studies in application of ancillary studies on cell blocks from salivary gland (SG) FNAs. This multi-institutional study evaluates the role of ancillary studies performed on cell blocks in the diagnosis of SG lesions, and their impact on clinical management.
Method: The electronic pathology archives of three large academic institutions were searched for SG FNAs with ancillary studies performed on cell blocks. The patient demographics, FNA site, cytologic diagnosis, ancillary studies, and surgical follow-up were recorded. If needed, the cytologic diagnoses were reclassified as per the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC).
Results: 117 SG FNA cases were identified including 3, 10, 11, 6, 23, 4, and 60 cases in MSRSGC categories I, II, III, IVa, IVb, V, VI, respectively with surgical follow-up available ranging from 27% to 100% within each category. Ancillary studies including histochemistry, immunocytochemistry (IHC), and in situ hybridization (ISH) were beneficial in 60%-100% of cases in each category. Risk of malignancy was 100% in both the suspicious for malignancy (V) and malignant (VI) categories. Ancillary studies improved diagnosis in 60% of non-neoplastic cases (II, 6/10), 100% of benign neoplasm cases (IVa, 6/6), and 98.3% of malignant cases (VI, 59/60).
Conclusion: Judicious and case-based ancillary studies performed on SG FNA cell blocks with sufficient material can improve the diagnostic yield by further characterization of the atypical/neoplastic cells, particularly in MSRSGC categories IVa-VI.
(© 2022 The Authors. Diagnostic Cytopathology published by Wiley Periodicals LLC.)
