Noncanonical Wnt5a/JNK Signaling Contributes to the Development of D-Gal/LPS-Induced Acute Liver Failure.

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Tytuł:: Noncanonical Wnt5a/JNK Signaling Contributes to the Development of D-Gal/LPS-Induced Acute Liver Failure.
Autorzy:: Ji XF; Department of Hepatology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, China.
Fan YC; Department of Hepatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.; Institute of Hepatology, Shandong University, Jinan, 250012, China.
Sun F; Department of Hepatology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, China.
Wang JW; Department of Hepatology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, China.
Wang K; Department of Hepatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. .; Institute of Hepatology, Shandong University, Jinan, 250012, China. .; Hepatology Institute of Shandong University, Wenhuaxi Road 107#, 250012, Jinan, Shandong, China. .
Źródło:: Inflammation [Inflammation] 2022 Jun; Vol. 45 (3), pp. 1362-1373. Date of Electronic Publication: 2022 Jan 31.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers
Original Publication: New York, Plenum Press.
MeSH Terms:: Galactosamine*/toxicity
Liver Failure, Acute*/chemically induced
Liver Failure, Acute*/metabolism
Animals ; Cytokines/metabolism ; Lipopolysaccharides/pharmacology ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Tumor Necrosis Factor-alpha/metabolism
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Grant Information:: ZR2019PH104 Innovative Research Group Project of the National Natural Science Foundation of China; 81970522 National Natural Science Foundation of China; 2020QNQT11 Shandong University multidisciplinary research and innovation team of young scholars; 2020M672074 China Postdoctoral Science Foundation; QDKY2017QN13 Scientific Research Foundation of Qilu Hospital of Shandong University (Qingdao); tsqn202103169 the Young Taishan Scholars
Contributed Indexing:: Keywords: Acute liver failure; Macrophage; Wnt5a; c-Jun N-terminal kinase
Substance Nomenclature:: 0 (Cytokines)
0 (Lipopolysaccharides)
0 (Tumor Necrosis Factor-alpha)
7535-00-4 (Galactosamine)
Entry Date(s):: Date Created: 20220131 Date Completed: 20220516 Latest Revision: 20220516
Update Code:: 20240104
DOI:: 10.1007/s10753-022-01627-y
PMID:: 35098406
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Acute liver failure (ALF) is a deadly clinical disorder with few effective treatments and unclear pathogenesis. In our previous study, we demonstrated that aberrant Wnt5a expression was involved in acute-on-chronic liver failure. However, the role of Wnt5a in ALF is unknown. We investigated the expression of Wnt5a and its downstream c-Jun N-terminal kinase (JNK) signaling in a mouse model of ALF established by coinjection of D-galactosamine (D-Gal) and lipopolysaccharide (LPS) in C57BL/6 mice. We also investigated the role of Box5, a Wnt5a antagonist, in vivo. Moreover, the effect of Wnt5a/JNK signaling on downstream inflammatory cytokine expression, phagocytosis, and migration in THP-1 macrophages was studied in vitro. Aberrant Wnt5a expression and JNK activation were detected in D-Gal/LPS-induced ALF mice. Box5 pretreatment reversed JNK activation and eventually decreased the mortality rate of D-Gal/LPS-treated mice, with reduced hepatic necrosis and apoptosis, serum ALT and AST levels, and liver inflammatory cytokine expression, although the latter was not significant. We further demonstrated that recombinant Wnt5a (rWnt5a)-induced tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) mRNA expression and increased THP-1 macrophage phagocytosis in a JNK-dependent manner, which could be restored by Box5. In addition, rWnt5a-induced migration of THP-1 macrophages was also reversed by Box5. Our findings suggested that Wnt5a/JNK signaling plays an important role in the development of ALF and that Box5 could have particular hepatoprotective effects in ALF.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

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