[Neurological symptoms of hypomagnesemia].

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Tytuł:: [Neurological symptoms of hypomagnesemia].
Autorzy:: Cakici M; Maasstad Ziekenhuis, afd. Neurologie, Rotterdam.; Contact: Michel Cakici ().
van Steenkiste J; Maasstad Ziekenhuis, afd. Interne Geneeskunde, Rotterdam.
Assink JH; Maasstad Ziekenhuis, afd. Neurologie, Rotterdam.
Moudrous W; Maasstad Ziekenhuis, afd. Interne Geneeskunde, Rotterdam.
Transliterated Title:: Neurologische symptomen bij hypomagnesiëmie.
Źródło:: Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 2021 Nov 25; Vol. 165. Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:: Case Reports; Journal Article
Język:: Dutch; Flemish
Imprint Name(s):: Publication: 2017?-: Amsterdam : Vereniging NTvG
Original Publication: Houten : Bohn Stafleu van Loghum
MeSH Terms:: Hypocalcemia*/chemically induced
Hypokalemia*/chemically induced
Magnesium Deficiency*/chemically induced
Magnesium Deficiency*/complications
Magnesium Deficiency*/diagnosis
Aged, 80 and over ; Female ; Humans ; Magnesium ; Proton Pump Inhibitors/adverse effects
Substance Nomenclature:: 0 (Proton Pump Inhibitors)
I38ZP9992A (Magnesium)
Entry Date(s):: Date Created: 20220207 Date Completed: 20220304 Latest Revision: 20220304
Update Code:: 20240104
PMID:: 35129888
: Czasopismo naukowe

Background: An epileptic seizure is a common neurological presentation in the Emergency Department (ED). Electrolyte disturbances are an important cause of neurological symptoms like seizures and hypomagnesemia is one of them. PPI's can cause hypomagnesemia and are readily prescribed. Therefore patients taking PPI's are at risk of developing neurological symptoms due to hypomagnesemia.
Case: A 82-year old woman was seen in ED with a history of nausea, vomiting and vertigo. A vertical nystagmus was observed with attacks of mydriasis followed by a phase of encephalopathy and restlessness. These were recognized as epilepsy. Hypokaliemia, hypocalcemia and a deep hypomagnesemia were present. The PPI accounted for hypomagnesemia. After 2 days of intravenous magnesium suppletion all symptoms disappeared.
Conclusion: PPI's can cause hypomagnesemia and magnesium levels should be obtained in patients presenting with encephalopathy or atypical neurological symptoms.

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