Disinhibitory Circuitry Gates Associative Synaptic Plasticity in Olfactory Cortex.

Tytuł:: Disinhibitory Circuitry Gates Associative Synaptic Plasticity in Olfactory Cortex.
Autorzy:: Canto-Bustos M; Department of Neuroscience.; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Friason FK; Department of Neuroscience.; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Bassi C; Department of Neuroscience.
Oswald AM; Department of Neuroscience .; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.; Department of Neurobiology.; Neuroscience Institute, University of Chicago, Chicago, Illinois 60637.
Źródło:: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2022 Apr 06; Vol. 42 (14), pp. 2942-2950. Date of Electronic Publication: 2022 Feb 18.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Washington, DC : Society for Neuroscience
Original Publication: [Baltimore, Md.] : The Society, c1981-
MeSH Terms:: Interneurons*/physiology
Piriform Cortex*/metabolism
Animals ; Female ; Male ; Mice ; Neural Inhibition/physiology ; Neuronal Plasticity/physiology ; Parvalbumins/metabolism ; Pyramidal Cells/physiology ; Vasoactive Intestinal Peptide/metabolism
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Contributed Indexing:: Keywords: circuit; cortex; inhibition; olfactory; plasticity
Substance Nomenclature:: 0 (Parvalbumins)
37221-79-7 (Vasoactive Intestinal Peptide)
Entry Date(s):: Date Created: 20220219 Date Completed: 20220408 Latest Revision: 20221007
Update Code:: 20240105
PubMed Central ID:: PMC8985865
DOI:: 10.1523/JNEUROSCI.1369-21.2021
PMID:: 35181596
: Czasopismo naukowe

Inhibitory microcircuits play an essential role in regulating cortical responses to sensory stimuli. Interneurons that inhibit dendritic or somatic integration act as gatekeepers for neural activity, synaptic plasticity, and the formation of sensory representations. Conversely, interneurons that selectively inhibit other interneurons can open gates through disinhibition. In the anterior piriform cortex, relief of inhibition permits associative LTP of excitatory synapses between pyramidal neurons. However, the interneurons and circuits mediating disinhibition have not been elucidated. In this study, we use an optogenetic approach in mice of both sexes to identify the inhibitory interneurons and disinhibitory circuits that regulate LTP. We focused on three prominent interneuron classes: somatostatin (SST), parvalbumin (PV), and vasoactive intestinal polypeptide (VIP) interneurons. We find that LTP is gated by the inactivation SST or PV interneurons and by the activation of VIP interneurons. Further, VIP interneurons strongly inhibit putative SST cells during LTP induction but only weakly inhibit PV interneurons. Together, these findings suggest that VIP interneurons mediate a disinhibitory circuit that gates synaptic plasticity during the formation of olfactory representations. SIGNIFICANCE STATEMENT Inhibitory interneurons stabilize neural activity during sensory processing. However, inhibition must also be modulated to allow sensory experience shape neural responses. In olfactory cortex, inhibition regulates activity-dependent increases in excitatory synaptic strength that accompany odor learning. We identify two inhibitory interneuron classes that act as gatekeepers preventing excitatory enhancement. We demonstrate that driving a third class of interneurons inhibits the gatekeepers and opens the gate for excitatory enhancement. All three inhibitory neuron classes comprise disinhibitory microcircuit motifs found throughout the cortex. Our findings suggest that a common disinhibitory microcircuit promotes changes in synaptic strength during sensory processing and learning.
(Copyright © 2022 the authors.)

Comment in: J Neurosci. 2022 Aug 24;42(34):6484-6486. (PMID: 36002284)

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