Modeling genetic diseases in nonhuman primates through embryonic and germline modification: Considerations and challenges.

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Tytuł:: Modeling genetic diseases in nonhuman primates through embryonic and germline modification: Considerations and challenges.
Autorzy:: Schmidt JK; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Jones KM; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Van Vleck T; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Emborg ME; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Źródło:: Science translational medicine [Sci Transl Med] 2022 Mar 02; Vol. 14 (634), pp. eabf4879. Date of Electronic Publication: 2022 Mar 02.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Review
Język:: English
Imprint Name(s):: Original Publication: Washington, DC : American Association for the Advancement of Science
MeSH Terms:: Germ Cells*
Primates*/genetics
Animals ; Disease Models, Animal ; Embryo, Mammalian
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Grant Information:: UG3 NS111688 United States NS NINDS NIH HHS; K99 HD099154 United States HD NICHD NIH HHS; P51 OD011106 United States OD NIH HHS; R33 NS115102 United States NS NINDS NIH HHS; R61 NS115102 United States NS NINDS NIH HHS
Entry Date(s):: Date Created: 20220302 Date Completed: 20220406 Latest Revision: 20230415
Update Code:: 20240104
PubMed Central ID:: PMC9373237
DOI:: 10.1126/scitranslmed.abf4879
PMID:: 35235338
: Czasopismo naukowe

Genetic modification of the embryo or germ line of nonhuman primates is envisioned as a method to develop improved models of human disease, yet the promise of such animal models remains unfulfilled. Here, we discuss current methods and their limitations for producing nonhuman primate genetic models that faithfully genocopy and phenocopy human disease. We reflect on how to ethically maximize the translational relevance of such models in the search for new therapeutic strategies to treat human disease.

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