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Tytuł:
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The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study.
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Autorzy:
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Tang C; State Key Laboratory of Molecular Vaccinology and Molecular Diagnotics, School of Public Health, Xiamen University, No. 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, 361102, Fujian, People's Republic of China.
Jiang H; Xiamen Guankou Hospital, No. 270 Jingshan Road, Jimei District, Xiamen, 361023, Fujian, People's Republic of China.
Zhao B; Clinical Medical Laboratory, Xiang'an Hospital of Xiamen University, No. 2000, East Xiang'an Road, Xiamen, 361102, Fujian, People's Republic of China.
Lin Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnotics, School of Public Health, Xiamen University, No. 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, 361102, Fujian, People's Republic of China.
Lin S; State Key Laboratory of Molecular Vaccinology and Molecular Diagnotics, School of Public Health, Xiamen University, No. 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, 361102, Fujian, People's Republic of China.
Chen T; State Key Laboratory of Molecular Vaccinology and Molecular Diagnotics, School of Public Health, Xiamen University, No. 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, 361102, Fujian, People's Republic of China.
Su Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnotics, School of Public Health, Xiamen University, No. 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, 361102, Fujian, People's Republic of China.
Zhang Y; Department of Nephrology, The Second Affiliated Hospital of Xiamen Medical College, No. 566 Shengguang Road, Jimei District, Xiamen, 361021, Fujian, People's Republic of China.
Zhou L; Department of Nephrology, The Second Affiliated Hospital of Xiamen Medical College, No. 566 Shengguang Road, Jimei District, Xiamen, 361021, Fujian, People's Republic of China.
Li L; Xiamen Guankou Hospital, No. 270 Jingshan Road, Jimei District, Xiamen, 361023, Fujian, People's Republic of China.
Lin J; Xiamen Guankou Hospital, No. 270 Jingshan Road, Jimei District, Xiamen, 361023, Fujian, People's Republic of China.
Lu Z; State Key Laboratory of Molecular Vaccinology and Molecular Diagnotics, School of Public Health, Xiamen University, No. 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, 361102, Fujian, People's Republic of China.
Wang Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnotics, School of Public Health, Xiamen University, No. 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, 361102, Fujian, People's Republic of China.
Zhao Z; State Key Laboratory of Molecular Vaccinology and Molecular Diagnotics, School of Public Health, Xiamen University, No. 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, 361102, Fujian, People's Republic of China.
Liu L; Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, 3141 Chestnut Street, Philadelphia, PA, USA.
Wang Y; Department of Nephrology, The Second Affiliated Hospital of Xiamen Medical College, No. 566 Shengguang Road, Jimei District, Xiamen, 361021, Fujian, People's Republic of China. .
Zhang J; State Key Laboratory of Molecular Vaccinology and Molecular Diagnotics, School of Public Health, Xiamen University, No. 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, 361102, Fujian, People's Republic of China. .
Shen H; State Key Laboratory of Molecular Vaccinology and Molecular Diagnotics, School of Public Health, Xiamen University, No. 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, 361102, Fujian, People's Republic of China. .
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Źródło:
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Journal of translational medicine [J Transl Med] 2022 Mar 04; Vol. 20 (1), pp. 108. Date of Electronic Publication: 2022 Mar 04.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: [London] : BioMed Central, 2003-
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MeSH Terms:
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Bilirubin*
Hypertension*
Adult ; Aging ; China/epidemiology ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Prospective Studies ; Risk Factors
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References:
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Grant Information:
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No. 22076157 National Natural Science Foundation of China; No. 20720190074 Fundamental Research Funds for the Central Universities; 2019D015 Planning Guidance Project of Fujian Provincial Department of Science and Technology
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Contributed Indexing:
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Keywords: Ageing; Bilirubin; Cohort study; Hypertension
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Substance Nomenclature:
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RFM9X3LJ49 (Bilirubin)
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Entry Date(s):
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Date Created: 20220305 Date Completed: 20220321 Latest Revision: 20220321
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Update Code:
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20240105
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PubMed Central ID:
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PMC8895624
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DOI:
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10.1186/s12967-022-03309-7
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PMID:
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35246141
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Background: Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study.
Methods: Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan-Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose-response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities.
Results: 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00-66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01-1.05) and 1.05 (1.03-1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92-0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose-response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk.
Conclusions: Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated.
(© 2022. The Author(s).)
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