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Tytuł:
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Osteoporosis in men.
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Autorzy:
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Vilaca T; Department of Oncology and Metabolism, Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield, UK. Electronic address: .
Eastell R; Department of Oncology and Metabolism, Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield, UK.
Schini M; Department of Oncology and Metabolism, Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield, UK.
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Źródło:
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The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2022 Apr; Vol. 10 (4), pp. 273-283. Date of Electronic Publication: 2022 Mar 02.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: London : The Lancet, Diabetes & Endocrinology, [2013]-
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MeSH Terms:
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Bone Density Conservation Agents*/therapeutic use
Osteoporosis*/diagnosis
Osteoporosis*/epidemiology
Osteoporosis*/therapy
Bone Density ; Diphosphonates/therapeutic use ; Female ; Humans ; Male ; Teriparatide/therapeutic use
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Grant Information:
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MR/P020941/1 United Kingdom MRC_ Medical Research Council
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Substance Nomenclature:
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0 (Bone Density Conservation Agents)
0 (Diphosphonates)
10T9CSU89I (Teriparatide)
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Entry Date(s):
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Date Created: 20220305 Date Completed: 20220421 Latest Revision: 20230315
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Update Code:
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20240105
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DOI:
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10.1016/S2213-8587(22)00012-2
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PMID:
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35247315
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Osteoporosis in men is a common but often overlooked disorder by clinicians. The criterion for osteoporosis diagnosis in men is similar to that in women-namely, a bone mineral density (BMD) that is 2·5 standard deviations or more below the mean for the young adult population (aged 20-29 years; T-score -2·5 or lower), measured at the hip or lumbar spine. Sex steroids are important for bone health in men and, as in women, oestrogens have a key role. Most men generally have bigger and stronger bones than women and typically have less bone loss during their lifetime. Men typically fracture less often than women, although they have a higher mortality rate after a fracture. Secondary osteoporosis is more common in men than in women. Lifestyle changes, adequate calcium, vitamin D intake, and exercise programmes are recommended for the management of osteoporosis in men. Bisphosphonates, denosumab, and teriparatide have been shown to increase BMD and are used for pharmacological treatment. In this Review, we report an updated overview of osteoporosis in men, describe new treatments and concepts, and discuss persistent controversies in the area.
Competing Interests: Declaration of Interests RE reports grants from Amgen, Immunodiagnostic Systems, Alexion, Roche, and Nittobo; and personal fees from IDS, GSK Nutrition, Mereo, Sandoz, Nittobo, Samsung, Haoma Medica, Elsevier, CL Bio, and University of California at San Francisco. TV and MS declare no competing interests.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
