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Tytuł pozycji:

The study of human serum metabolome on the health effects of glyphosate and early warning of potential damage.

Tytuł:
The study of human serum metabolome on the health effects of glyphosate and early warning of potential damage.
Autorzy:
Zhang Q; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Liu X; Department of Occupational Disease, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, 210009, China.
Gao M; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Li X; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Wang Y; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Chang Y; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Zhang X; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Huo Z; Department of Occupational Disease, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, 210009, China.
Zhang L; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Shan J; Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatics, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address: .
Zhang F; Department of Occupational Disease, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, 210009, China. Electronic address: .
Zhu B; Department of Occupational Disease, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, 210009, China. Electronic address: .
Yao W; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address: .
Źródło:
Chemosphere [Chemosphere] 2022 Jul; Vol. 298, pp. 134308. Date of Electronic Publication: 2022 Mar 14.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford, New York, : Pergamon Press.
MeSH Terms:
Glycine*/analogs & derivatives
Glycine*/toxicity
Herbicides*/toxicity
Metabolome*
Biomarkers ; Humans ; Metabolomics ; Glyphosate
Contributed Indexing:
Keywords: Biomarkers; Glyphosate; Human exposure; Metabolomics; Serum
Substance Nomenclature:
0 (Biomarkers)
0 (Herbicides)
TE7660XO1C (Glycine)
Entry Date(s):
Date Created: 20220318 Date Completed: 20220506 Latest Revision: 20231213
Update Code:
20240105
DOI:
10.1016/j.chemosphere.2022.134308
PMID:
35302001
Czasopismo naukowe
Glyphosate is one of the most widely used herbicide with high efficiency, low toxicity and broad-spectrum. In recent decades, increasing evidence suggests that glyphosate may cause adverse health effects on human beings. However, until now, there is little data on the human metabolic changes. Since occupational workers are under greater health risks than ordinary people, the understanding regarding the health effects of glyphosate on occupational workers is very important for the early warning of potential damage. In this study, serum metabolic alterations in workers from three chemical factories were analyzed by gas chromatography-mass spectrometry (GC-MS) to assess the potential health risks caused by glyphosate at the molecular level. It was found that the levels of 27 metabolites changed significantly in the exposed group compared to the controls. The altered metabolic pathways, including amino acid metabolism, energy metabolism (glycolysis and TCA cycle) and glutathione metabolism (oxidative stress), etc., indicated a series of changes occur in health profile of the human body after glyphosate exposure, and the suboptimal health status of human may further evolve into various diseases, such as Parkinson's disease, renal and liver dysfunction, hepatocellular carcinoma, and colorectal cancer. Subsequently, 4 biomarkers (i.e., benzoic acid, 2-ketoisocaproic acid, alpha-ketoglutarate, and monoolein) were identified as potential biomarkers related to glyphosate exposure based on the partial correlation analyses, linear regression analyses, and FDR correction. Receiver-operating curve (ROC) analyses manifested that these potential biomarkers and their combinational pattern had good performance and potential clinical value to assess the potential health risk associated with glyphosate exposure while retaining high accuracy. Our findings provided new insights on mechanisms of health effects probably induced by glyphosate, and may be valuable for the health risk assessment of glyphosate exposure.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)

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