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Tytuł:
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Clinical Relevance of Anti-Gliadin Seropositivity in the Ageing Population: A Long-term Follow-up Study.
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Autorzy:
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Ruuskanen AT; Department of Neurology, Päijät-Häme Joint Authority for Health and Wellbeing; Lahti, Finland. .
Luostarinen L; Department of Neurology, Päijät-Häme Joint Authority for Health and Wellbeing; Lahti, Finland. .
Huhtala H; Faculty of Social Sciences, Tampere University, Tampere, Finland. .
Valve R; Department of Nutrition, Päijät-Häme Joint Authority for Health and Wellbeing, Lahti, Finland. .
Kaukinen K; Department of Internal Medicine, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. .
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Źródło:
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Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2022 Mar 19; Vol. 31 (1), pp. 11-17. Date of Electronic Publication: 2022 Mar 19.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Cluj-Napoca, Romania : Editura Medicală Universitară "Iuliu Haţieganu", c2006-
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MeSH Terms:
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Celiac Disease*/diagnosis
Celiac Disease*/epidemiology
Gliadin*
Aging ; Follow-Up Studies ; Glutens ; Humans ; Immunoglobulin A
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Substance Nomenclature:
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0 (Immunoglobulin A)
8002-80-0 (Glutens)
9007-90-3 (Gliadin)
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Entry Date(s):
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Date Created: 20220320 Date Completed: 20220427 Latest Revision: 20221205
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Update Code:
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20240105
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DOI:
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10.15403/jgld-4025
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PMID:
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35306543
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Aims: To explore if anti-gliadin antibody (AGA) positivity is associated with overall mortality or morbidity and especially with the development of coeliac disease during long-term gluten exposure.
Methods: The study population comprised 130 persistently AGA-positive but transglutaminase-2 (anti- TG2) -negative and 52 persistently AGA- and anti-TG2 -negative subjects aged 64-88 years. HLA-typing for DQ2 and DQ8 (coeliac-type HLA) was performed on the AGA-positives. The medical records of the study population were reviewed to compare mortality and morbidity during a long-term follow-up of 12-13 years since the initial antibody analysis.
Results: Mortality or cumulative prevalence of gastroenterological, autoimmune, psychiatric, cardiovascular or any malignant diseases did not differ statistically between the AGA-positives and the AGA-negatives. Neurological diseases were more common in the AGA-negative group (p=0.017), but there was no statistical difference between the prevalence of any particular neurological diseases. Coeliac-type HLA in AGA-positive subjects did not influence mortality or morbidity. However, during the last six to seven years the incidence of immunological diseases was more common in the AGA-positive subjects without coeliac-type HLA than in those with coeliac-type HLA, or in the AGA-negative group (p=0.020). None of the persistently AGA-positive subjects developed clinically diagnosed coeliac disease.
Conclusions: Gliadin antibody positivity without coeliac disease does not predict mortality or morbidity in the ageing population continuing to consume gluten for over ten years.
Comment in: J Gastrointestin Liver Dis. 2022 Sep 16;31(3):368-358. (PMID: 36112711)
