Diagnostic Value of MRI Combined with CXCR4 Expression Level in Lymph Node Metastasis Head and Neck Squamous Cell Carcinoma.

Tytuł:: Diagnostic Value of MRI Combined with CXCR4 Expression Level in Lymph Node Metastasis Head and Neck Squamous Cell Carcinoma.
Autorzy:: Zhao J; Department of Oncology, Cangzhou Central Hospital, Cangzhou, Hebei 061000, China.
Li X; Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou, Hebei 061000, China.
Wang M; Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou, Hebei 061000, China.
Liu F; Department of Nuclear Magnetic Resonance, Cangzhou Central Hospital, Cangzhou, Hebei 061000, China.
Wang J; Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou, Hebei 061000, China.
Źródło:: Computational and mathematical methods in medicine [Comput Math Methods Med] 2022 Mar 08; Vol. 2022, pp. 4073918. Date of Electronic Publication: 2022 Mar 08 (Print Publication: 2022).
Typ publikacji:: Journal Article; Retracted Publication
Język:: English
Imprint Name(s):: Publication: 2011- : New York : Hindawi
Original Publication: London : Taylor & Francis, c2006-
MeSH Terms:: Head and Neck Neoplasms/*diagnostic imaging
Head and Neck Neoplasms/*immunology
Lymphatic Metastasis/*diagnostic imaging
Lymphatic Metastasis/*immunology
Receptors, CXCR4/*metabolism
Squamous Cell Carcinoma of Head and Neck/*diagnostic imaging
Squamous Cell Carcinoma of Head and Neck/*immunology
Aged ; Biomarkers, Tumor/metabolism ; Computational Biology ; Female ; Head and Neck Neoplasms/pathology ; Humans ; Logistic Models ; Lymphatic Metastasis/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Squamous Cell Carcinoma of Head and Neck/secondary
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Substance Nomenclature:: 0 (Biomarkers, Tumor)
0 (CXCR4 protein, human)
0 (Receptors, CXCR4)
Entry Date(s):: Date Created: 20220321 Date Completed: 20220328 Latest Revision: 20230804
Update Code:: 20240105
PubMed Central ID:: PMC8924604
DOI:: 10.1155/2022/4073918
PMID:: 35309836
: Czasopismo naukowe

Pełny tekst

Objective: To explore the diagnostic value of magnetic resonance imaging (MRI) combined with CXCR4 expression levels in lymph node metastasis of the head and neck squamous cell carcinoma (HNSCC).
Methods: 289 patients with HNSCC were divided into lymph node metastasis group (LNM group, n = 171) and non-LNM group ( n = 118) according to the pathological examination results. MRI was used to scan the patient's lesions and cervical lymph nodes, and ADC was measured by MRI diffusion weighting imaging. The expression of CXCR4 in tumor tissues was detected by qRT-PCR. Logistic regression was used to analyze the risk factors of HNSCC lymph node metastasis. ROC curve was used to analyze the diagnostic effects of MRI, CXCR4, and MRI combined with CXCR4 on HNSCC lymph node metastasis.
Results: Compared with the non-LNM group, patients in the LNM group had a lower degree of pathological differentiation, and the positive rate of TNM staging and vascular invasion was higher. The signal intensity of T1WI and T2WI were low intensity and high intensity, respectively, and the ADC value was significantly reduced. At the same time, the expression level of CXCR4 in the tumor tissues of the LNM group was also significantly increased. In addition, compared with MRI and CXCR4 used alone, MRI combined with CXCR4 has a higher predictive value.
Conclusion: MRI has a good effect in demonstrating lymph node metastasis. CXCR4 is significantly upregulated in lymph node metastasis tumor tissue. The combination of the two can be used for clinical diagnosis of HNSCC lymph node metastasis.
Competing Interests: The authors claim that there is no conflict of interest between them.
(Copyright © 2022 Jin Zhao et al.)

Retraction in: Comput Math Methods Med. 2023 Jul 26;2023:9754632. (PMID: 37538469)

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