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Tytuł:
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Cueing emotional memories during slow wave sleep modulates next-day activity in the orbitofrontal cortex and the amygdala.
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Autorzy:
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Pereira SIR; School of Psychology, Cardiff University Brain Research Imaging Centre, Cardiff, Wales, CF24 4HQ, UK. Electronic address: .
Tsimpanouli ME; School of Psychological Sciences, University of Manchester, Manchester, M13 9PL, UK.
Hutchison I; School of Psychological Sciences, University of Manchester, Manchester, M13 9PL, UK.
Schneider J; School of Psychology, Cardiff University Brain Research Imaging Centre, Cardiff, Wales, CF24 4HQ, UK; School of Psychological Sciences, University of Manchester, Manchester, M13 9PL, UK.
Anderson IM; School of Psychological Sciences, University of Manchester, Manchester, M13 9PL, UK.
McFarquhar M; School of Psychological Sciences, University of Manchester, Manchester, M13 9PL, UK.
Elliott R; School of Psychological Sciences, University of Manchester, Manchester, M13 9PL, UK.
Lewis PA; School of Psychology, Cardiff University Brain Research Imaging Centre, Cardiff, Wales, CF24 4HQ, UK; School of Psychological Sciences, University of Manchester, Manchester, M13 9PL, UK.
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Źródło:
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NeuroImage [Neuroimage] 2022 Jun; Vol. 253, pp. 119120. Date of Electronic Publication: 2022 Mar 21.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Orlando, FL : Academic Press, c1992-
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MeSH Terms:
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Memory Consolidation*/physiology
Sleep, Slow-Wave*/physiology
Amygdala/diagnostic imaging ; Emotions/physiology ; Humans ; Memory/physiology ; Prefrontal Cortex ; Sleep/physiology
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Grant Information:
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United Kingdom BB_ Biotechnology and Biological Sciences Research Council
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Contributed Indexing:
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Keywords: Arousal; Emotional memory; Fmri; Orbitofrontal cortex; Sleep; Spatial memory task; Sws; Targeted memory reactivation
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Entry Date(s):
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Date Created: 20220325 Date Completed: 20220425 Latest Revision: 20220505
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Update Code:
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20240105
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DOI:
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10.1016/j.neuroimage.2022.119120
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PMID:
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35331867
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Emotional memories are preferentially consolidated during sleep, through the process of memory reactivation. Targeted memory reactivation (TMR) has been shown to boost memory consolidation during sleep, but its neural correlates remain unclear, particularly for emotional memories. Here, we aimed to examine how TMR of emotional material during slow wave sleep (SWS) impacts upon neural processing during a subsequent arousal rating task. Participants were trained on a spatial memory task including negative and neutral pictures paired with semantically matching sounds. The picture-sound pairs were rated for emotional arousal before and after the spatial memory task. Then, half of the sounds from each emotional category (negative and neutral) were cued during SWS. The next day, participants were retested on both the arousal rating and the spatial memory task inside an MRI scanner, followed by another retest session a week later. Memory consolidation and arousal processing did not differ between cued and non-cued items of either emotional category. We found increased responses to emotional stimuli in the amygdala and orbitofrontal cortex (OFC), and a cueing versus emotion interaction in the OFC, whereby cueing neutral stimuli led to an increase in OFC activity, while cueing negative stimuli led to decreased OFC activation. Interestingly, the effect of cueing on amygdala activation was modulated by time spent in REM sleep. We conclude that SWS TMR impacts OFC activity, while REM sleep plays a role in mediating the effect of such cueing on amygdala.
(Copyright © 2022. Published by Elsevier Inc.)
