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Tytuł:
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Metastatic cancer along ancient Silk Road: A possible case from Xinjiang (China).
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Autorzy:
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He L; School of History and Culture, Department of Archaeology and Museology, Lanzhou University, Lanzhou, Gansu 730000, China. Electronic address: .
Gibbon VE; Division of Clinical Anatomy & Biological Anthropology, Department of Human Biology, University of Cape Town, Observatory 7935, South Africa.
Xiao X; School of Ethnology and Sociology, Minzu University of China, Beijing 100081, China.
Wang B; Xinjiang Uygur Autonomous Region Museum, Urumqi 830000, China.
Li H; School of Ethnology and Sociology, Minzu University of China, Beijing 100081, China. Electronic address: .
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Źródło:
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International journal of paleopathology [Int J Paleopathol] 2022 Jun; Vol. 37, pp. 23-29. Date of Electronic Publication: 2022 Mar 30.
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Typ publikacji:
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Historical Article; Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: : Amsterdam : Elsevier
Original Publication: [New York, NY] : Elsevier
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MeSH Terms:
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Carcinoma*/secondary
Cemeteries ; China ; History, Ancient ; Humans ; Male ; Skull/pathology
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Contributed Indexing:
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Keywords: CT imaging; Multiple osteolytic lesions; Sampula cemetery, Xinjiang
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Entry Date(s):
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Date Created: 20220402 Date Completed: 20220615 Latest Revision: 20220625
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Update Code:
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20240104
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DOI:
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10.1016/j.ijpp.2022.03.001
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PMID:
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35366493
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Objective: Palaeopathological evidence of cancer, especially metastatic cancer, is rare in China. This paper describes and diagnoses a cranium with multiple lytic lesions recovered from the Sampula cemetery in Xinjiang, attempting to diagnose the type of disease that could have caused the pathological lesions observed.
Material: A cranium from an adult male (#00106) was recovered from the Sampula cemetery (dated to 55 BCE to 335 CE) located in the Luopu County, the Hotan River oasis on the southern edge of the Tarim Basin in southern Xinjiang.
Methods: The cranium was assessed macroscopically and radiographically (CT).
Results: Multiple osteolytic lesions with irregular and "moth-eaten" margins were detected in cranium #00106. CT scans revealed the development of the lesions began at the diploe and identified a "button sequestrum".
Conclusions: Based on lesion characteristics, metastatic carcinoma was likely the cause of lesions found in cranium #00106.
Significance: This case has expanded our knowledge of the malignant neoplasms of ancient populations in northwest China and discusses the possible risk factors in the occurrence of cancer in the Sampula site, as well as the possible impacts of skeletal metastases on the individual.
Limitations: The distribution of osteolytic lesions over the complete skeleton cannot be observed because of the unavailability of postcranial bone.
Suggestions for Future Research: With the increasing number of reports describing diseases in ancient China, the patterns of diseases occurrence and development can be further explored from spatial and temporal perspectives.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
