-
Tytuł:
-
Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments.
-
Autorzy:
-
Shiraki T; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Ichibori Y; Department of Cardiology, Osaka Police Hospital, Osaka, Japan.
Ohtani T; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan. Electronic address: .
Mizote I; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Kioka H; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Tsukamoto Y; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Nakamura D; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Yokoi K; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Ide S; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Nakamoto K; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Takeda Y; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Kotani JI; Cardiovascular Institute of Therapeutic Evaluation and Creation, Sapporo Cardiovascular Clinic for Asia Medical Group, Sapporo, Japan.
Hikoso S; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Sawa Y; Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Sakata Y; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
-
Źródło:
-
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2022 Jul; Vol. 41 (7), pp. 877-885. Date of Electronic Publication: 2022 Mar 16.
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Publication: 1999- : New York, NY : Elsevier
Original Publication: St. Louis, Mo. : Mosby-Year Book, Inc., c1991-
-
MeSH Terms:
-
Coronary Artery Disease*/diagnostic imaging
Coronary Artery Disease*/surgery
Heart Transplantation*/adverse effects
Plaque, Atherosclerotic*/diagnostic imaging
Plaque, Atherosclerotic*/etiology
Plaque, Atherosclerotic*/immunology
Allografts ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/immunology ; Cytokines/immunology ; Humans ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Ultrasonography, Interventional/methods
-
Contributed Indexing:
-
Keywords: cardiac allograft vasculopathy; heart transplantation; interleukin-31; intravascular ultrasound; optical coherence tomography
-
Substance Nomenclature:
-
0 (Cytokines)
-
Entry Date(s):
-
Date Created: 20220411 Date Completed: 20220629 Latest Revision: 20221004
-
Update Code:
-
20240105
-
DOI:
-
10.1016/j.healun.2022.03.007
-
PMID:
-
35400587
-
Background: Detailed morphological characteristics of de novo and donor-transmitted plaques and the association of serum T-lymphocyte cytokine levels with plaque progression of coronary allograft vasculopathy within 1 year after heart transplantation are unknown.
Methods: In this retrospective analysis of data in a prospectively maintained database, 40 heart transplant recipients were included. We performed serial 3 vessel optical coherence tomography and intravascular ultrasound analyses, at the 8 week (baseline) and 12 month post-transplantation follow-ups, and serum cytokine measurements (n = 23). The correlation between serum cytokines and Δplaque burden (between baseline and follow-up) was evaluated depending on plaque morphology.
Results: Thirteen de novo plaques (maximum intimal thickness ≥0.5 mm at the 12 month follow-up without plaques at baseline) were identified in 8 recipients, and 31 donor-transmitted plaques (maximum intimal thickness ≥0.5 mm at baseline) were detected in 17 recipients. Compared with donor-transmitted plaques, the Δplaque burden in the de novo plaques, with mainly fibrous morphology, was high (38.8% [29.6%-41.2%] vs 8.7% [1.33%-13.6%], p < 0.001). Stratification of the morphology of donor-transmitted plaques revealed that the Δplaque burden in fibrous plaques (10.6% [7.0%-18.0%]) was similar to that in fibroatheroma (10.3% [8.7%-23.8%]). Serum interleukin-31 levels at baseline correlated with fibrous plaque proliferation (r = 0.73, p = 0.007) even under immunosuppressive conditions, whereas other cytokines (interleukin-1β, interleukin-17, and interferon-gamma) were mostly undetectable.
Conclusions: Intimal fibrous proliferation contributed to the progression of donor-transmitted and de novo plaques. Serum interleukin-31 levels at baseline may contribute to intimal fibrous proliferation within 1 year after heart transplantation.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Comment in: J Heart Lung Transplant. 2022 Jul;41(7):886-888. (PMID: 35474249)
