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Tytuł pozycji:

Corn oligopeptides inhibit Akt/NF-κB signaling pathway and inflammatory factors to ameliorate CCl 4 -induced hepatic fibrosis in mice.

Tytuł:
Corn oligopeptides inhibit Akt/NF-κB signaling pathway and inflammatory factors to ameliorate CCl 4 -induced hepatic fibrosis in mice.
Autorzy:
Feng XW; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Cheng QL; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Fang L; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Liu WY; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.; Engineering Laboratory for Agro Biomass Recycling & Valorizing, College of Engineering, China Agricultural University, Beijing, People's Republic of China.
Liu LW; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.; College of Food Science, Northeast Agricultural University, Harbin, People's Republic of China.
Sun CQ; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.; College of Food Science, Northeast Agricultural University, Harbin, People's Republic of China.
Lu ZH; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Li GM; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Gu RZ; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Źródło:
Journal of food biochemistry [J Food Biochem] 2022 Aug; Vol. 46 (8), pp. e14162. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 2008- : Hoboken, NJ : Wiley
Original Publication: Westport, Conn. : Food & Nutrition Press
MeSH Terms:
NF-kappa B*/genetics
NF-kappa B*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Animals ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Mice ; Oligopeptides/pharmacology ; Signal Transduction ; Zea mays/metabolism
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Grant Information:
Z191100002819001 Beijing Science and Technology Innovation Base Cultivation and Development Program; 2021BEG02027 Key Research and Development Program of Ningxia Hui Autonomous Region; 2017YFE0108800 Programs of International Cooperation in Science and Technology Innovation of China and Mongolian; 2016YFD0400604 National Key Research and Development Program of China; 31671963 National Natural Science Foundation of China; International Cooperation; Research and Development
Contributed Indexing:
Keywords: Akt/NF-κB; corn oligopeptides; hepatic fibrosis; inflammatory; liver injury
Substance Nomenclature:
0 (NF-kappa B)
0 (Oligopeptides)
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
Entry Date(s):
Date Created: 20220411 Date Completed: 20220810 Latest Revision: 20220930
Update Code:
20240105
DOI:
10.1111/jfbc.14162
PMID:
35404510
Czasopismo naukowe
In this study, the effect of corn oligopeptides (COPs) with liver protection activity on mice with hepatic fibrosis (HF) induced by carbon tetrachloride (CCl 4 ) was studied. It was proved that COPs can ameliorate the liver injury and inflammation caused by CCl 4 by histopathology and enzyme-linked immunosorbent assay in mice. The expression of Akt/NF-κB inflammatory pathway was determined by real-time polymerase chain reaction (RT-PCR) and western blotting (WB). The results showed that COPs inhibited the expression of key proteins in the inflammatory pathway. In conclusion, the results of this study suggested that COPs could improve CCl 4 -induced HF by improving liver injury, reducing the expression of inflammatory factors, and inhibiting the expression of inflammatory signaling pathways. PRACTICAL APPLICATIONS: The corns around the world are mainly used as animal feed, and the liver protective activity of corn oligopeptides (COPs) is rarely applied to the market. The development of COPs liver protective food can prevent the occurrence of liver-related diseases such as hepatic fibrosis to a certain extent. Developing COPs liver protecting food can improve the utilization value of corn. It is hoped that this study can provide experimental support for the application of COPs in liver protection food.
(© 2022 Wiley Periodicals LLC.)
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