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Tytuł:
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Stress, hypoglycemia, and the autonomic nervous system.
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Autorzy:
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Haas A; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
Borsook D; Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.
Adler G; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
Freeman R; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: .
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Źródło:
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Autonomic neuroscience : basic & clinical [Auton Neurosci] 2022 Jul; Vol. 240, pp. 102983. Date of Electronic Publication: 2022 Apr 04.
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Typ publikacji:
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Journal Article; Review; Research Support, N.I.H., Extramural
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Język:
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English
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Imprint Name(s):
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Original Publication: [Amsterdam ; New York] : Elsevier, c2000-
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MeSH Terms:
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Autonomic Nervous System*
Hypoglycemia*
Baroreflex/physiology ; Blood Pressure/physiology ; Heart Rate/physiology ; Humans ; Sympathetic Nervous System/physiology
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Grant Information:
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K23 HL155076 United States HL NHLBI NIH HHS; R01 NS105844 United States NS NINDS NIH HHS
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Contributed Indexing:
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Keywords: Autonomic nervous system; Baroreflex; Hypoglycemia; Stress; Sympathetic nervous system
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Entry Date(s):
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Date Created: 20220413 Date Completed: 20220519 Latest Revision: 20231227
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Update Code:
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20231227
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DOI:
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10.1016/j.autneu.2022.102983
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PMID:
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35417827
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Stress can be classified as either psychosocial or physiologic. Physiologic stress refers to stresses due to acute illness, trauma, pain, hypoglycemia, and sleep deprivation-much less is known regarding its health consequences. This review focuses on hypoglycemia as a model to further investigate physiological stress. Experimental mild to moderate hypoglycemia is a paradigmatic physiological stress that evokes autonomic, neuroendocrine, and immune responses. Hypoglycemic stress is an ideal model to examine the interactions and consequences of physiological stress on the autonomic nervous system. Acute hypoglycemia has been demonstrated to increase inflammatory markers, prolong QTc, and impair cardiac-vagal baroreflex sensitivity. Some of these consequences may not reverse completely when euglycemia is restored. For example, there is attenuation of the cardiac-vagal baroreflex, attenuation of the vascular sympathetic baroreflex (muscle sympathetic nerve activity response to transient hypotension), and attenuation of the catecholamine response to lower body negative pressure that is present the next day after hypoglycemia has resolved.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
