Self-organized collective cell behaviors as design principles for synthetic developmental biology.

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Tytuł:: Self-organized collective cell behaviors as design principles for synthetic developmental biology.
Autorzy:: Hartmann J; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: .
Mayor R; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: .
Źródło:: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2023 May 30; Vol. 141, pp. 63-73. Date of Electronic Publication: 2022 Apr 18.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: London : Academic Press
Original Publication: London, UK : Academic Press, c1996-
MeSH Terms:: Synthetic Biology*
Developmental Biology*
Morphogenesis ; Cell Movement
Grant Information:: MR/S007792/1 United Kingdom MRC_ Medical Research Council; M008517 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; 102489/Z/13/Z United Kingdom WT_ Wellcome Trust
Contributed Indexing:: Keywords: Biomechanics; Cell sorting; Collective cell migration; Development; Morphogenesis; Neural crest; Patterning; Synthetic Biology
Entry Date(s):: Date Created: 20220422 Date Completed: 20230210 Latest Revision: 20230329
Update Code:: 20240104
DOI:: 10.1016/j.semcdb.2022.04.009
PMID:: 35450765
: Czasopismo naukowe

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Over the past two decades, molecular cell biology has graduated from a mostly analytic science to one with substantial synthetic capability. This success is built on a deep understanding of the structure and function of biomolecules and molecular mechanisms. For synthetic biology to achieve similar success at the scale of tissues and organs, an equally deep understanding of the principles of development is required. Here, we review some of the central concepts and recent progress in tissue patterning, morphogenesis and collective cell migration and discuss their value for synthetic developmental biology, emphasizing in particular the power of (guided) self-organization and the role of theoretical advances in making developmental insights applicable in synthesis.
Competing Interests: Declaration of Competing Interest The authors declare that there is no conflict of interest.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)

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