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Tytuł:
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Purple Corn Extract Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis.
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Autorzy:
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Kim HJ; Department of Pharmacology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju-si, Gangwon-do 26339, Republic of Korea.
Kim BH; Medience Co. Ltd., Chuncheon, Gangwon-do 24232, Republic of Korea.
Jin BR; Department of Pharmacology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju-si, Gangwon-do 26339, Republic of Korea.
Park SJ; Medience Co. Ltd., Chuncheon, Gangwon-do 24232, Republic of Korea.
An HJ; Department of Pharmacology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju-si, Gangwon-do 26339, Republic of Korea.
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Źródło:
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Journal of agricultural and food chemistry [J Agric Food Chem] 2022 May 11; Vol. 70 (18), pp. 5561-5569. Date of Electronic Publication: 2022 Apr 25.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Washington, American Chemical Society.
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MeSH Terms:
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Prostatic Hyperplasia*/drug therapy
Prostatic Hyperplasia*/genetics
Prostatic Hyperplasia*/metabolism
Testosterone Propionate*
Animals ; Anthocyanins/metabolism ; Apoptosis ; Cell Proliferation ; Dihydrotestosterone/metabolism ; Humans ; Male ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Plant Extracts/pharmacology ; Prostate ; Rats ; Rats, Sprague-Dawley ; Testosterone/metabolism ; Zea mays/genetics ; Zea mays/metabolism
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Contributed Indexing:
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Keywords: androgen receptor; apoptosis; benign prostatic hyperplasia; dihydrotestosterone; purple corn husk and cob extracts
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Substance Nomenclature:
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0 (Anthocyanins)
0 (Plant Extracts)
08J2K08A3Y (Dihydrotestosterone)
3XMK78S47O (Testosterone)
WI93Z9138A (Testosterone Propionate)
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Entry Date(s):
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Date Created: 20220425 Date Completed: 20220512 Latest Revision: 20220512
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Update Code:
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20240104
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DOI:
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10.1021/acs.jafc.1c07955
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PMID:
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35466676
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Purple corn ( Zea mays L.), utilized as a natural pigment in food production and processing, has been used to treat obesity, cystitis, and urinary tract infections. However, no reports of its use for benign prostatic hyperplasia (BPH) exist. Purple corn extract (PCE) contains anthocyanins, particularly cyanidin-3- O -glucoside, which have various pharmacological characteristics. Therefore, this study sought to elucidate the ameliorative effect of PCE on BPH in dihydrotestosterone (DHT)-stimulated WPMY-1 cells and testosterone propionate (TP)-induced rats. Expression levels of the upregulated androgen receptor (AR) and its related genes in DHT-stimulated WPMY-1 cells were reduced by PCE, and proapoptotic gene expression increased by modulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling cascade. PCE reduced the weight of the enlarged prostate by inhibiting the androgen/AR signaling-related markers. Histological variations in the prostate epithelium caused by TP injection were restored by PCE. Thus, PCE alleviates BPH by modulating prostate cell proliferation and apoptosis.
