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Tytuł pozycji:

Exploring Factors Influencing Medication Compliance in Saudi Rheumatoid Arthritis Patients: A Nationwide Cross-Sectional Survey - Results from the COPARA Study.

Tytuł:
Exploring Factors Influencing Medication Compliance in Saudi Rheumatoid Arthritis Patients: A Nationwide Cross-Sectional Survey - Results from the COPARA Study.
Autorzy:
Omair MA; Rheumatology Unit, Department of Medicine, King Saud University, Riyadh, Saudi Arabia.
Alshehri MM; College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Altokhais NA; College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Aljanobi GA; Rheumatology Unit, Department of Medicine, Qatif Central Hospital, Qatif, Saudi Arabia.
El Dessougi MI; Rheumatology Unit, Department of Medicine, Security Forces Hospital, Riyadh, Saudi Arabia.
AlHarthi A; Rheumatology Unit, Department of Medicine, Security Forces Hospital, Riyadh, Saudi Arabia.
Omair MA; Department of Statistics and Operations Research, College of Science, King Saud University, Riyadh, Saudi Arabia.
Attar SM; Rheumatology Unit, Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Bahlas SM; Rheumatology Unit, Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Alfurayj AS; Rheumatology Unit, Department of Medicine, Buraidah Central Hospital, Buraidah, Saudi Arabia.
Alazmi MS; Rheumatology Unit, Department of Medicine, Prince Mohammed Medical City, Sakaka-Aljouf, Saudi Arabia.
Asiri AM; Rheumatology Unit, Department of Medicine, Aseer Central Hospital, Abha, Saudi Arabia.
AlOmair MM; Rheumatology Unit, Department of Medicine, Aseer Central Hospital, Abha, Saudi Arabia.
Al Juffali L; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Almalag HM; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Źródło:
Patient preference and adherence [Patient Prefer Adherence] 2022 Apr 26; Vol. 16, pp. 1105-1114. Date of Electronic Publication: 2022 Apr 26 (Print Publication: 2022).
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: [Auckland, N.Z.] : Dove Press Limited
References:
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Contributed Indexing:
Keywords: Saudi Arabia; compliance; rheumatoid arthritis
Entry Date(s):
Date Created: 20220503 Latest Revision: 20220506
Update Code:
20240104
PubMed Central ID:
PMC9056069
DOI:
10.2147/PPA.S363477
PMID:
35502428
Czasopismo naukowe
Purpose: Compliance is essential to achieve treatment goals in rheumatoid arthritis (RA) patients. The current study evaluated compliance and related factors in a large and diverse population.
Patients and Methods: Patients with RA who received active treatment were invited to participate in an online survey. The Arabic versions of the 5-Item Compliance Questionnaire for Rheumatology (ACQR-5) and the RA Impact of Disease (RAID) were used to measure compliance and disability, respectively. The patients were sub-grouped based on background disease-modifying anti-rheumatic drugs (DMARDs). Variables associated with high compliance were selected for the logistic regression analysis.
Results: A total of 1241 patients completed the survey and were included in the final analysis. Of those, 1055 (85%) were females with a mean (±SD) age and disease duration of 47.14 ± 13.71 and 8.77 ± 7.43 years, respectively. The mean RAID was 4.4±2.58, with 980 (79%) having an unacceptable level state. Patients with an unacceptable RAID level had a lower compliance rate (78.8% vs 85.8%, p = 0.001). Demographics associated with high compliance were female sex and increased age, with reported odds ratios of 1.018 (95% CI: 1.007-1.028) and 1.464 (95% CI: 1.016-2.108), respectively. Compliance was similar between patients on Janus kinase inhibitors or biological DMARDs (88.14% vs 80.83%, p = 0.17), between monotherapy, double therapy, or triple therapy recipients (80% vs 82.23% vs 81.32%, p = 0.665), and between patients receiving injectable and oral therapy (77.32% vs 81.14%, p = 0.246).
Conclusion: A high compliance level was observed in this population, with patient demographics influencing compliance rather than the medication type or route of administration. Interventional studies should focus on the of high-risk patients identified in this study.
Competing Interests: The authors report no conflicts of interest in this work.
(© 2022 Omair et al.)
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