A case of febrile infection-related epilepsy syndrome (FIRES) in young adult: still a diagnostic and therapeutic challenge.

Tytuł:: A case of febrile infection-related epilepsy syndrome (FIRES) in young adult: still a diagnostic and therapeutic challenge.
Autorzy:: Acampora R; Neurology-Stroke Unit, Ospedale del Mare Hospital, Naples, Italy. .
Quiroga Subirana P; Neurology-University Hospital of Torrecardenas, Almeria, Spain.
Durante L; Neurology-Stroke Unit, Ospedale del Mare Hospital, Naples, Italy.
Tonziello R; Medicine-Rizzoli Hospital, Ischia, Italy.
Aversano G; Faculty of Medicine, University of Naples 'L. Vanvitelli', Naples, Italy.
Lieto M; Neurology-Stroke Unit, Ospedale del Mare Hospital, Naples, Italy.
Ripa P; Neurology-Stroke Unit, Ospedale del Mare Hospital, Naples, Italy.
Mazzaferro MP; Neurology-Stroke Unit, Ospedale del Mare Hospital, Naples, Italy.
Źródło:: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2022 Jul; Vol. 43 (7), pp. 4555-4558. Date of Electronic Publication: 2022 May 04.
Typ publikacji:: Case Reports; Journal Article
Język:: English
Imprint Name(s):: Original Publication: Milano, Italy : Springer-Verlag Italia, c2000-
MeSH Terms:: Drug Resistant Epilepsy*/diagnosis
Encephalitis*/complications
Epilepsy*/etiology
Epileptic Syndromes*/complications
Epileptic Syndromes*/diagnosis
Epileptic Syndromes*/therapy
Immune System Diseases*/complications
Status Epilepticus*/complications
Status Epilepticus*/diagnosis
Humans ; Seizures/complications ; Young Adult
References:: Hon KL, Leung AKC, Torres AR (2018) Febrile Infection-Related Epilepsy Syndrome (FIRES): An Overview of Treatment and Recent Patents. Recent Pat Inflamm Allergy Drug Discov 12(2):128–135. https://doi.org/10.2174/1872213X12666180508122450. (PMID: 10.2174/1872213X1266618050812245029745347)
Milligan TA, Zamani A, Bromfield E (2009) Frequency and patterns of MRI abnormalities due to status epilepticus. Seizure 18(2):104–108. https://doi.org/10.1016/j.seizure.2008.07.004. (PMID: 10.1016/j.seizure.2008.07.00418723376)
Mantoan Ritter L, Nashef L (2021) New-onset refractory status epilepticus (NORSE). Pract Neurol 2021 21:119–127. (PMID: 10.1136/practneurol-2020-002534)
Kantanen AM, Reinikainen M, Parviainen I, Kälviäinen R (2017) Long-term outcome of refractory status epilepticus in adults: a retrospective population-based study. Epilepsy Res 133:13–21. https://doi.org/10.1016/j.eplepsyres.2017.03.009. (PMID: 10.1016/j.eplepsyres.2017.03.00928402834)
Leitinger M, Trinka E, Giovannini G, Zimmermann G, Florea C, Rohracher A, Kalss G, Neuray C, Kreidenhuber R, Höfler J, Kuchukhidze G, Granbichler C, Dobesberger J, Novak HF, Pilz G, Meletti S, Siebert U (2019) Epidemiology of status epilepticus in adults: a population-based study on incidence, causes, and outcomes. Epilepsia 60(1):53–62. https://doi.org/10.1111/epi.14607. (PMID: 10.1111/epi.1460730478910)
Tan RY, Neligan A, Shorvon SD (2010) The uncommon causes of status epilepticus: a systematic review. Epilepsy Res 91(2–3):111–122. https://doi.org/10.1016/j.eplepsyres.2010.07.015. (PMID: 10.1016/j.eplepsyres.2010.07.01520709500)
Serrano-Castro PJ, Quiroga-Subirana P, Payan-Ortiz M, Fernandez-Perez J (2013) The expanding spectrum of febrile infection-related epilepsy syndrome (FIRES). Seizure 22:153–155. https://doi.org/10.1016/j.seizure.2012.11.006. (PMID: 10.1016/j.seizure.2012.11.00623237766)
Contributed Indexing:: Keywords: Antiepileptic drugs (AED); Epilepsy; FIRES; Immunoglobulin; NORSE
Entry Date(s):: Date Created: 20220504 Date Completed: 20220623 Latest Revision: 20220717
Update Code:: 20240104
PubMed Central ID:: PMC9064715
DOI:: 10.1007/s10072-022-06106-8
PMID:: 35507191
: Czasopismo naukowe

Pełny tekst

A new onset of status epilepticus in a previously healthy adult preceded by a recent minor febrile infection represents a diagnostic and therapeutic challenge in clinical practice. Considering the broad spectrum of epileptic encephalopathies caused by autoimmune mechanisms, differential diagnosis for new-onset refractory status epilepticus (NORSE) should include febrile infection-related epilepsy syndrome (FIRES), in order to not underestimate the underlying etiological condition triggering epilepsy in non-epileptic patients (Hon et al. in Recent Pat Inflamm Allergy Drug Discov 12:128-135, 2018). We report a case of acute encephalopathy with refractory seizures after a febrile illness (FIRES) in a young adult with complete remission of symptoms as well as dramatic improvement of EEG abnormalities following intravenous immunoglobulin and proper antiepileptic medications. We conducted an extensive workup including lumbar puncture, blood tests, EEG serial monitoring, MRI brain, total body CT scan, and PET brain with FDG to shed light on the etiology of the disease.
(© 2022. Fondazione Società Italiana di Neurologia.)

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