The novel concept of "Onco-Immuno-Endocrinology" led to the discovery of new clinical entity "paraneoplastic autoimmune hypophysitis".

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Tytuł:: The novel concept of "Onco-Immuno-Endocrinology" led to the discovery of new clinical entity "paraneoplastic autoimmune hypophysitis".
Autorzy:: Takahashi Y; Nara Medical University, Department of Diabetes and Endocrinology, Japan. Electronic address: .
Źródło:: Best practice & research. Clinical endocrinology & metabolism [Best Pract Res Clin Endocrinol Metab] 2022 May; Vol. 36 (3), pp. 101663. Date of Electronic Publication: 2022 Apr 26.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2002- : Amsterdam : Elsevier
Original Publication: Amsterdam : Harcourt Publishers, c2001-
MeSH Terms:: Autoimmune Hypophysitis*/diagnosis
Endocrine System Diseases*
Endocrinology*
Hypophysitis*/diagnosis
Hypophysitis*/etiology
Neoplasms*
Pituitary Diseases*/complications
Pituitary Diseases*/diagnosis
Autoantibodies ; Humans
Contributed Indexing:: Keywords: hypophysitis; onco-immuno-endocrinology; paraneoplastic autoimmune hypophysitis; paraneoplastic syndrome; pituitary
Substance Nomenclature:: 0 (Autoantibodies)
Entry Date(s):: Date Created: 20220507 Date Completed: 20220530 Latest Revision: 20220610
Update Code:: 20240105
DOI:: 10.1016/j.beem.2022.101663
PMID:: 35525821
: Czasopismo naukowe

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Recent advances in tumor immunology have enabled to develop immune checkpoint inhibitors and to save many patients with advanced cancer. Various endocrine diseases are caused by autoimmune mechanisms; it is important to understand that many endocrine organs are targeted by autoimmunity. In addition, some of malignant tumors ectopically produce hormones and lead to a clinically relevant ectopic hormone syndrome as an endocrine paraneoplastic syndrome. Thus, interplay between oncology, immunology, and endocrinology is important. We have defined a new clinical entity "paraneoplastic autoimmune hypophysitis" as "hypophysitis associated with autoimmunity against pituitary antigens caused by an ectopic expression of these antigens in the tumor and resulting in a breakdown of immune tolerance". To understand the pathophysiology of paraneoplastic autoimmune hypophysitis requires a fusion of the fields of oncology, immunology, and endocrinology; therefore, I propose a new concept of Onco-Immuno-Endocrinology.
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