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Tytuł:
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Simultaneous Daily Fecal Microbiota Transplantation Fails to Prevent Metronidazole-Induced Dysbiosis of Equine Gut Microbiota.
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Autorzy:
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Kinoshita Y; Microbiology Division, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan. Electronic address: .
Niwa H; Microbiology Division, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
Uchida-Fujii E; Microbiology Division, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
Nukada T; Microbiology Division, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
Ueno T; Microbiology Division, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
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Źródło:
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Journal of equine veterinary science [J Equine Vet Sci] 2022 Jul; Vol. 114, pp. 104004. Date of Electronic Publication: 2022 May 06.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2003- : New York : Elsevier
Original Publication: [Wildomar, CA : William E. Jones, c1981-
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MeSH Terms:
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Dysbiosis*/chemically induced
Dysbiosis*/veterinary
Gastrointestinal Microbiome*
Horse Diseases*/chemically induced
Animals ; Fecal Microbiota Transplantation/methods ; Fecal Microbiota Transplantation/veterinary ; Feces/microbiology ; Horses ; Metronidazole
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Contributed Indexing:
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Keywords: Fecal microbiota transplantation; Horse; Metagenome; Metronidazole
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Substance Nomenclature:
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140QMO216E (Metronidazole)
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Entry Date(s):
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Date Created: 20220508 Date Completed: 20220614 Latest Revision: 20220929
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Update Code:
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20240105
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DOI:
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10.1016/j.jevs.2022.104004
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PMID:
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35526726
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Antimicrobial administration can lead to imbalances of gastrointestinal microbiota, called dysbiosis. Dysbiosis sometimes results in diarrhea and enteritis in horses. Fecal microbiota transplantation (FMT) is used to treat affected horses, but whether it is effective as a prophylactic approach for dysbiosis in horses receiving antimicrobials remains unknown. The aim of this study was to assess the efficacy of simultaneous FMT against metronidazole-induced dysbiosis in horses. Changes in the ratios of bacterial families, determined by metagenomic analysis, were similar between the metronidazole-treated group and the simultaneous metronidazole- and FMT-treated group, notably in the Clostridiaceae, Ruminococcaceae, and Enterobacteriaceae. Differences in fecal bacterial compositions were due mainly to metronidazole administration (P = .0003), but not to FMT (P = .3136). Simultaneous FMT at 500 g of donor feces in 1 L of suspension once a day did not inhibit metronidazole-induced dysbiosis. The results show that the FMT protocol needs to be improved to prevent metronidazole-induced gut dysbiosis in horses.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
