Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis.

Szczegóły
Abstrakt

Tytuł:: Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis.
Autorzy:: Eskandari E; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Eaves CJ; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada.
Źródło:: The Journal of cell biology [J Cell Biol] 2022 Jun 06; Vol. 221 (6). Date of Electronic Publication: 2022 May 12.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: New York : Rockefeller University Press
MeSH Terms:: Carcinogenesis*/genetics
Caspase 3*/physiology
Cell Proliferation*
Cell Survival*/genetics
Apoptosis/genetics ; Humans ; Saccharomyces cerevisiae
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Grant Information:: 21296 Canadian Cancer Society Research Institute; University of British Columbia
Substance Nomenclature:: EC 3.4.22.- (Caspase 3)
Entry Date(s):: Date Created: 20220513 Date Completed: 20220517 Latest Revision: 20220716
Update Code:: 20240105
PubMed Central ID:: PMC9106709
DOI:: 10.1083/jcb.202201159
PMID:: 35551578
: Czasopismo naukowe

Caspase-3 is a widely expressed member of a conserved family of proteins, generally recognized for their activated proteolytic roles in the execution of apoptosis in cells responding to specific extrinsic or intrinsic inducers of this mode of cell death. However, accumulating evidence indicates that caspase-3 also plays key roles in regulating the growth and homeostatic maintenance of both normal and malignant cells and tissues in multicellular organisms. Given that yeast possess an ancestral caspase-like gene suggests that the caspase-3 protein may have acquired different functions later during evolution to better meet the needs of more complex multicellular organisms, but without necessarily losing all of the functions of its ancestral yeast precursor. This review provides an update on what has been learned about these interesting dichotomous roles of caspase-3, their evolution, and their potential relevance to malignant as well as normal cell biology.
(© 2022 Eskandari and Eaves.)

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