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Tytuł:
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Polystyrene micro and nano-particles induce metabolic rewiring in normal human colon cells: A risk factor for human health.
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Autorzy:
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Bonanomi M; ISBE. IT/ Centre of Systems Biology, Piazza Della Scienza 4, 20126, Milan, Italy; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza Della Scienza 2, 20126, Milan, Italy.
Salmistraro N; ISBE. IT/ Centre of Systems Biology, Piazza Della Scienza 4, 20126, Milan, Italy; Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, MI, Italy.
Porro D; ISBE. IT/ Centre of Systems Biology, Piazza Della Scienza 4, 20126, Milan, Italy; Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, MI, Italy.
Pinsino A; Institute of Translational Pharmacology (IFT), National Research Council (CNR), Palermo, PA, Italy.
Colangelo AM; ISBE. IT/ Centre of Systems Biology, Piazza Della Scienza 4, 20126, Milan, Italy; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza Della Scienza 2, 20126, Milan, Italy.
Gaglio D; ISBE. IT/ Centre of Systems Biology, Piazza Della Scienza 4, 20126, Milan, Italy; Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, MI, Italy. Electronic address: .
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Źródło:
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Chemosphere [Chemosphere] 2022 Sep; Vol. 303 (Pt 1), pp. 134947. Date of Electronic Publication: 2022 May 14.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford, New York, : Pergamon Press.
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MeSH Terms:
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Plastics*
Water Pollutants, Chemical*/analysis
Colon ; Humans ; Microplastics/toxicity ; Polystyrenes/toxicity ; Risk Factors
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Contributed Indexing:
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Keywords: Metabolomics; Plastic pollution; Risk factor
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Substance Nomenclature:
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0 (Microplastics)
0 (Plastics)
0 (Polystyrenes)
0 (Water Pollutants, Chemical)
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Entry Date(s):
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Date Created: 20220517 Date Completed: 20220628 Latest Revision: 20220628
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Update Code:
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20240105
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DOI:
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10.1016/j.chemosphere.2022.134947
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PMID:
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35580641
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Polystyrene is a thermoplastic polymer widely used in commercial products. Like all plastics, polystyrene can be degraded into microplastic and nanoplastic particles and ingested via food chain contamination. Although the ecological impact due to plastic contamination is well known, there are no studies indicating a carcinogenic potential of polystyrene microplastics (MPs) and nanoplastics (NPs). Here, we evaluated the effects of the MPs and NPs on normal human intestinal CCD-18Co cells. Our results show that internalization of NPs and MPs induces metabolic changes under both acute and chronic exposure by inducing oxidative stress, increasing glycolysis via lactate to sustain energy metabolism and glutamine metabolism to sustain anabolic processes. We also show that this decoupling of nutrients mirrors the effect of the potent carcinogenic agent azoxymethane and HCT15 colon cancer cells, carrying out the typical strategy of cancer cells to optimize nutrients utilization and allowing metabolic adaptation to environmental stress conditions. Taken together our data provide new evidence that chronic NPs and MPs exposure could act as cancer risk factor for human health.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
