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Tytuł:
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The impact of essential and toxic elements on cardiometabolic risk factors in adults and older people.
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Autorzy:
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Nunes FLDS; Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-900 Natal, Rio Grande do Norte, Brazil. Electronic address: .
Lima SCVC; Department of Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-900 Natal, Rio Grande do Norte, Brazil. Electronic address: .
Lyra CO; Department of Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-900 Natal, Rio Grande do Norte, Brazil. Electronic address: .
Marchioni DM; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo Campus, Av. Dr. Arnaldo, 715 - Cerqueira César, 01246-904 São Paulo, SP, Brazil. Electronic address: .
Pedrosa LFC; Department of Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-900 Natal, Rio Grande do Norte, Brazil. Electronic address: .
Barbosa Junior F; Laboratory of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, Ribeirão Preto Campus, Av. do Café, s/n - Monte Alegre, Ribeirão Preto, 14040-903 São Paulo, SP, Brazil. Electronic address: .
Sena-Evangelista KCM; Department of Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Lagoa Nova, 59078-900 Natal, Rio Grande do Norte, Brazil. Electronic address: .
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Źródło:
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Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2022 Jul; Vol. 72, pp. 126991. Date of Electronic Publication: 2022 May 06.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Stuttgart : Gustav Fisher
Original Publication: Stuttgart ; New York : Gustav Fischer, c1995-
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MeSH Terms:
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Arsenic*/urine
Cadmium*/urine
Cardiometabolic Risk Factors*
Adult ; Aged ; Body Mass Index ; C-Reactive Protein ; Copper ; Cross-Sectional Studies ; Humans ; Mercury/urine ; Middle Aged ; Risk Factors ; Selenium/urine ; Zinc/urine
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Contributed Indexing:
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Keywords: Cardiovascular risk; Dyslipidemia; Heavy metals; Hyperglycemia; Hypertension; Trace elements
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Substance Nomenclature:
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00BH33GNGH (Cadmium)
789U1901C5 (Copper)
9007-41-4 (C-Reactive Protein)
FXS1BY2PGL (Mercury)
H6241UJ22B (Selenium)
J41CSQ7QDS (Zinc)
N712M78A8G (Arsenic)
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Entry Date(s):
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Date Created: 20220521 Date Completed: 20220603 Latest Revision: 20220606
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Update Code:
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20240105
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DOI:
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10.1016/j.jtemb.2022.126991
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PMID:
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35597099
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Background and Aim: Evidence suggests an association between essential and toxic elements and the worsening of cardiometabolic risk factors. This study aimed to investigate the concentrations of zinc, copper, selenium, arsenic, cadmium, and mercury and their relationship with cardiometabolic risk factors in adults and older people.
Methods: This cross-sectional study was carried out with 112 adults with a mean age of 59 (sd 14) years old and a BMI of 29.30 (sd 5.11) Kg/m 2 . The subject's weight and height were measured for body mass index (BMI) calculation, classified according to the cut-off points recommended by the World Health Organization (WHO). We evaluated sociodemographic, clinical, lifestyle, waist circumference - WC, visceral adiposity index - VAI, glycemic lipid profile, blood pressure, and high-sensitive C-reactive protein (hs-CRP). Cardiovascular risk was defined by The Global Risk Score (GRS) score. Plasma zinc, selenium, copper levels, urinary arsenic, cadmium, and mercury levels were measured using the inductively coupled plasma mass spectrometry technique (ICP-MS).
Results: There was a negative association between urinary arsenic and VAI (β - 0.03, p < 0.01), triglycerides (β - 1.10, p < 0.01), and VLDL cholesterol (β - 0.14, p = 0.02). Plasma copper and copper/zinc ratio were positively associated with fasting glucose and hs-CRP (β 0.38, p < 0.01; β 36.02, p = 0.01, β 0.004, p < 0.01, β 0.68, p < 0.001, respectively). Urinary arsenic (β - 0.14, p = 0.04) and cadmium (β - 36.42, p = 0.04) were negatively associated with systolic blood pressure. Also, urinary cadmium was negatively associated with diastolic blood pressure (β - 21.55, p = 0.03), and urinary mercury showed an opposite behavior (β 1.45, p = 0.03).
Conclusion: Essential and toxic elements in urine and plasma could be potential biomarkers for cardiovascular risk factors. A healthy lifestyle should be adopted; in addition, government policies should be developed to guarantee sustainable production and a safe environment.
(Copyright © 2022. Published by Elsevier GmbH.)
