Minor impact on fertility in men with inflammatory bowel disease: A National Cohort Study from Sweden.

Tytuł:: Minor impact on fertility in men with inflammatory bowel disease: A National Cohort Study from Sweden.
Autorzy:: Druvefors E; Department of Surgery, County Hospital Ryhov, Jönköping, Sweden.; Department of Biomedical and Clinical Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Andersson RE; Department of Surgery, County Hospital Ryhov, Jönköping, Sweden.; Department of Biomedical and Clinical Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Hammar U; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.; Institute of environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Landerholm K; Department of Surgery, County Hospital Ryhov, Jönköping, Sweden.; Department of Biomedical and Clinical Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Myrelid P; Department of Biomedical and Clinical Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden.; Department of Surgery, Linköping University Hospital, Linköping, Sweden.
Źródło:: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2022 Jul; Vol. 56 (2), pp. 292-300. Date of Electronic Publication: 2022 May 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Oxford : Wiley-Blackwell
Original Publication: [Oxford, OX] : Blackwell Scientific Publications, [c1987-
MeSH Terms:: Colitis, Ulcerative*/therapy
Crohn Disease*/complications
Crohn Disease*/epidemiology
Crohn Disease*/therapy
Inflammatory Bowel Diseases*/complications
Inflammatory Bowel Diseases*/epidemiology
Inflammatory Bowel Diseases*/therapy
Chronic Disease ; Cohort Studies ; Fertility ; Humans ; Male ; Registries ; Sweden/epidemiology
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Contributed Indexing:: Keywords: Crohn’s disease; fertility; inflammatory bowel disease; men; ulcerative colitis
Entry Date(s):: Date Created: 20220523 Date Completed: 20220628 Latest Revision: 20220829
Update Code:: 20240105
PubMed Central ID:: PMC9322263
DOI:: 10.1111/apt.16984
PMID:: 35599362
: Czasopismo naukowe

Pełny tekst

Background and Aims: Onset of inflammatory bowel disease (IBD) in men is most common during childbearing age, but little is known about the impact on fertility. Previous studies of fertility in men were small, which justifies this large nation-based registry study.
Methods: Fertility was assessed in a national cohort of men with IBD aged 15-44 years in 1964-2014, identified from the Swedish National Patient Register, and in a reference cohort matched for age and place of residence (ratio 1:5). Information about childbirths was found in the Swedish Multi-Generation Register. Patients with indeterminate colitis or inconsistent IBD coding were classified as IBD-unclassified (IBD-U).
Results: The cohorts included 29,104 men with IBD and 140,901 matched individuals. IBD patients had a lower fertility rate (number of births per 1000 person years) compared with the matched individuals; 1.28 (SD 1.27) versus 1.35 (SD 1.31; p < 0.001). Fertility was somewhat impaired in all IBD subtypes compared with the matched cohort; ulcerative colitis (UC) (hazard ratio [HR] 0.93, 95% CI 0.91-0.96), Crohn's disease (CD) (HR 0.95, 95% CI 0.92-0.98) and IBD-U 0.92, 95% CI 0.89-0.95. The cumulated total parity and the parity progression were also decreased for all IBD subtypes. Within the IBD cohort disease severity, intensity of medical treatment (CD) and bowel surgery (IBD-U) were further associated with impaired fertility.
Conclusions: This nationwide cohort study shows only slightly impaired fertility in men with IBD.
(© 2022 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.)

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