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Tytuł:
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Association between quantitative bacterial culture of bronchoalveolar lavage fluid and antibiotic requirement in dogs with lower respiratory tract signs.
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Autorzy:
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Lebastard M; Centre Hospitalier Vétérinaire Frégis, Arcueil, France.
Beurlet-Lafarge S; Laboratoire Vebio, Arcueil, France.
Gomes E; Centre Hospitalier Vétérinaire Frégis, Arcueil, France.
Le Boedec K; Centre Hospitalier Vétérinaire Frégis, Arcueil, France.
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Źródło:
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Journal of veterinary internal medicine [J Vet Intern Med] 2022 Jul; Vol. 36 (4), pp. 1444-1453. Date of Electronic Publication: 2022 May 26.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <2010-> : Malden, MA : Wiley Periodicals
Original Publication: Philadelphia : J.B. Lippincott Co., [c1987-
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MeSH Terms:
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Dog Diseases*/diagnosis
Dog Diseases*/drug therapy
Dog Diseases*/microbiology
Respiratory Tract Infections*/veterinary
Animals ; Anti-Bacterial Agents/therapeutic use ; Bacteria ; Bronchoalveolar Lavage/veterinary ; Bronchoalveolar Lavage Fluid/microbiology ; Cross-Sectional Studies ; Dogs ; Respiratory System
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References:
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Contributed Indexing:
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Keywords: BAL; bronchitis; canine; colony forming unit; pneumonia
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
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Entry Date(s):
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Date Created: 20220526 Date Completed: 20220726 Latest Revision: 20220727
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Update Code:
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20240105
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PubMed Central ID:
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PMC9308423
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DOI:
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10.1111/jvim.16456
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PMID:
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35616218
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Background: Historically, positive bacterial cultures from the lower respiratory tract (LRT) have been considered clinically relevant when quantitative bacterial cultures of bronchoalveolar lavage fluid (BALF) were >1700 colony forming units (cfu)/mL. However, this threshold might not accurately predict a requirement for antibiotics.
Objectives: To study whether quantitative BALF bacterial culture results were predictive of antibiotic requirement in dogs with LRT signs.
Animals: Thirty-three client-owned dogs.
Methods: Cross-sectional study. Dogs with positive quantitative bacterial culture of BALF were included. Dogs were divided into 2 groups, depending on whether they had a LRT infection requiring antibiotics (LRTI-RA) or LRT disease not requiring antibiotics (LRTD-NRA), based on thoracic imaging features, presence of intracellular bacteria on BALF cytology, and response to treatment. Predictive effect of cfu/mL and BALF total nucleated cell count (TNCC) on antibiotic requirement, adjusting for ongoing or prior antibiotic therapy and age, were studied using logistic regression.
Results: Twenty-two and 11 dogs were included in the LRTI-RA and LRTD-NRA groups, respectively. The cfu/mL was not significantly predictive of antibiotic requirement, independent of ongoing or prior antibiotic treatment and age (LRTI-RA: median, 10 000 cfu/mL; range, 10-3 × 10 8 ; LRTD-NRA: median, 10 000 cfu/mL; range, 250-1.3 × 10 9 ; P = .27). The TNCC was not significantly predictive of antibiotic requirement when only dogs with bronchial disease were considered (LRTI-RA: median, 470 cells/μL; range, 240-2260; LRTD-NRA: median, 455 cells/μL; range, 80-4990; P = .57).
Conclusion and Clinical Importance: The cfu/mL is an inappropriate measure for determining whether antibiotics are of benefit in dogs with LRT signs.
(© 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)