-
Tytuł:
-
Pyridoxal water-soluble cobalt(II) helicates: Synthesis, structural analysis, and interactions with biomacromolecules.
-
Autorzy:
-
Martins FM; Laboratório de Materiais Inorgânicos, Departamento de Química, CCNE, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
Siqueira JD; Laboratório de Materiais Inorgânicos, Departamento de Química, CCNE, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
Iglesias BA; Laboratório de Bioinorgânica e Materiais Porfirínicos, Departamento de Química, CCNE, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
Chaves OA; Centro de Química de Coimbra, Departamento de Química, Universidade de Coimbra, Rua Larga, 3004-535 Coimbra, Portugal.
Back DF; Laboratório de Materiais Inorgânicos, Departamento de Química, CCNE, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil. Electronic address: .
-
Źródło:
-
Journal of inorganic biochemistry [J Inorg Biochem] 2022 Aug; Vol. 233, pp. 111854. Date of Electronic Publication: 2022 May 13.
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: New York, Elsevier.
-
MeSH Terms:
-
Cobalt*/chemistry
Pyridoxal*
DNA/chemistry ; Humans ; Ligands ; Serum Albumin, Human ; Water/chemistry
-
Contributed Indexing:
-
Keywords: Cobalt(II) complexes; Helicate; Molecular docking; Pyridoxal; Self-assembly
-
Substance Nomenclature:
-
0 (Ligands)
059QF0KO0R (Water)
3G0H8C9362 (Cobalt)
3THM379K8A (Pyridoxal)
9007-49-2 (DNA)
ZIF514RVZR (Serum Albumin, Human)
-
Entry Date(s):
-
Date Created: 20220531 Date Completed: 20220608 Latest Revision: 20220920
-
Update Code:
-
20240104
-
DOI:
-
10.1016/j.jinorgbio.2022.111854
-
PMID:
-
35636301
-
Helical complexes composed of organic ligand strands and metallic centers, called helicates, present interactions with biomacromolecules, such as deoxyribonucleic acid, as one of their main biological applications in bioinorganic chemistry. Despite the potential antineoplastic and antibacterial results of the interactions between helicates and biomacromolecules, there is still a gap of research in the literature, primarily in terms of solubility in aqueous media. In this study, we present the synthesis, structural analysis, and interaction with biomacromolecules of two water-soluble cobalt(II) double-stranded helicates: [Co II 2 L 2 2 ][Co II (NCS) 4 ]∙9H 2 O (C1) and [Co II 2 L 4 2 ]Cl 2 ∙11H 2 O (C2). These complexes are obtained from iminic ligands (L 2 and L 4 ) derived from pyridoxal, a vitamin B6 aldehyde derivative. Through spectroscopic assays, these helical complexes were shown to have weak and moderate binding capacities with calf-thymus deoxyribonucleic acid and human serum albumin, respectively. The theoretical assays suggest that C1 and C2 interact with the minor groove of deoxyribonucleic acid and have different main binding sites with human serum albumin. Furthermore, Van der Waals and hydrogen bonds were shown to be the main intermolecular forces for these C1-C2:biomacromolecules interactions.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
